CXCR4 Antagonist II - CAS 1258011-83-4 - Calbiochem C화학적 특성, 용도, 생산
일반 설명
A thiopseudourea compound that acts as a selective and highly potent CXCR4/Fusin antagonist (IC
50 = 1.1 nM against SDF-1/CXCL12-induced Ca
2+ mobilization in CEM cells) and effectively targets CXCR4-mediated binding of both CXCL12 (IC
50 = 8 and 11 nM in competitive binding assays using human CEM and rat IR983F membrane, respectively) and HIV gp120 (IC
50 = 7 nM in HIV attachment assays). Shown to be orally available in rat with good
in vivo pharmacokinetics (32% availability, t
max = 0.5 h, C
max= 18 ng/ml, t
1/2 = 7.6 h, based on an oral dose of 1 mg/kg). Comparing to AMD3100 (Cat. No.
239820), CXCR4 Antagonist II is ~30-times more potent as a CXCR4-CXCL12 interaction blocker, while being ~2-fold less potent in blocking gp120-mediated HIV attachment.
CXCR4 Antagonist II - CAS 1258011-83-4 - Calbiochem 준비 용품 및 원자재
원자재
준비 용품
