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Thymopentin

Thymopentin 구조식 이미지
카스 번호:
69558-55-0
상품명:
Thymopentin
동의어(영문):
TP-5;RKDVY;Immunox;Timunox;THYMOPETIN;THYMOPENTIN;Thymopentine;THYMOPENTIN 5;Sintomodulina;Thymopentin TP-5
CBNumber:
CB7491069
분자식:
C10H14OSn
포뮬러 무게:
268.93
MOL 파일:
69558-55-0.mol

Thymopentin 속성

저장 조건
−20°C
물리적 상태
Powder
색상
White
CAS 데이터베이스
69558-55-0(CAS DataBase Reference)

안전

WGK 독일 3

Thymopentin C화학적 특성, 용도, 생산

개요

Thymopentin is a kind of peptide. Peptides and polypeptides play a critical role in the immune system and are therefore predestined as a source for new approaches in immunotherapy. Thymopentin is capable of modulating the immune response. It is a fragment of the thymopoietins (TMPOs) which is a family of nuclear protein. Studies have shown that Thymopentin is capable of affecting the function of T cells and monocytes monitored by increased cGMP level and the triggering of cellular signaling. It is also capable of improve an imbalanced immune system. As an immunomodulating agent, it is clinically used in the treatment of autoimmune diseases such as atopic dermatitis, chronic lymphocytic leukemia, Sezary’s syndrome, rheumatoid arthritis and decreased immune competency. Recent study has also shown that its immuno-modulating effect can also help fight against the infection of mycobacterium tuberculosis.

Originator

Janssen (Belgium)

용도

immunoregulator

상표명

SINTOMODULINA; TIMUNOX

Clinical Use

Thymopentin is a synthetic, immunomodulating pentapeptide, representing the active fragment of the thymus hormone, thymopoietin. Thymopentin induces phenotypic differentiation and maturation of T-cells. It appears of value in the treatment of primary immune deficiency, rheumatoid arthritis, atopic dermatitis, sarcoidosis and a variety of other diseases with manifestations of disturbed immune balance.

참고 문헌

Zhang, Yan, et al. "Novel thymopentin release systems prepared from bioresorbable PLA–PEG–PLA hydrogels." International journal of pharmaceutics 386.1 (2010): 15-22.
Gonser, S., E. Weber, and G. Folkers. "Peptides and polypeptides as modulators of the immune response: thymopentin—an example with unknown mode of action." Pharmaceutica Acta Helvetiae 73.6 (1999): 265-273.
Wang, Ying, et al. "Synthetic modifications of the immunomodulating peptide thymopentin to confer anti-mycobacterial activity." Biomaterials 35.9 (2014): 3102-3109.

Thymopentin 준비 용품 및 원자재

원자재

준비 용품


Thymopentin 공급 업체

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