Pomalidomide-PEG2-butyl iodide

Pomalidomide-PEG2-butyl iodide 구조식 이미지
카스 번호:
1835705-72-0
상품명:
Pomalidomide-PEG2-butyl iodide
동의어(영문):
Pomalidomide-2-2-6-I;Pomalidomide-PEG2-butyl iodide;Acetamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-2-[2-[(6-iodohexyl)oxy]ethoxy]-;Crosslinker–E3 Ligase ligand conjugate, Pomalidomide-2-2-6-I, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-2-(2-((6-iodohexyl)oxy)ethoxy)acetamide, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
CBNumber:
CB74919985
분자식:
C23H28IN3O7
포뮬러 무게:
585.39
MOL 파일:
1835705-72-0.mol
MSDS 파일:
SDS

Pomalidomide-PEG2-butyl iodide 속성

끓는 점
757.7±60.0 °C(Predicted)
밀도
1.588±0.06 g/cm3(Predicted)
저장 조건
2-8°C
산도 계수 (pKa)
10.68±0.40(Predicted)

안전

Pomalidomide-PEG2-butyl iodide C화학적 특성, 용도, 생산

용도

Protein degrader builiding block Pomalidomide-PEG2-butyl Iodide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Pomalidomide-PEG2-butyl iodide 준비 용품 및 원자재

원자재

준비 용품


Pomalidomide-PEG2-butyl iodide 공급 업체

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