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멘톨

멘톨
멘톨 구조식 이미지
카스 번호:
89-78-1
한글명:
멘톨
동의어(한글):
멘톨;맨톨;디/엘-멘톨;(1알파,2베타,5알파), 5-베틸-2-(1-메틸에틸)-사이클로헥산올;멘타캄포;멘토멘트올;멘톨, 시스-1,3,트랜스-1,4-;사이클로헥산올, 5-메틸-2-(1-메틸에틸)-,(1알타,2베타,5알파)-;시스-1,3,트랜스-1,4-멘톨;페민트캄포;헥사히드로티몰
상품명:
DL-Menthol
동의어(영문):
Mentol;89-78-1;-MenthoL;I-menthol;DL - mint;DL-Menthol;MENTHOL(RG);MENTHOL 99;Menthol CRS;MENTHOL 99%
CBNumber:
CB7498497
분자식:
C10H20O
포뮬러 무게:
156.27
MOL 파일:
89-78-1.mol

멘톨 속성

녹는점
34-36 °C(lit.)
끓는 점
216 °C(lit.)
알파
-2 º (c=10, EtOH)
밀도
0.89 g/mL at 25 °C(lit.)
증기압
0.8 mm Hg ( 20 °C)
굴절률
1.4615
FEMA
2665 | MENTHOL RACEMIC
인화점
200 °F
저장 조건
Store below +30°C.
용해도
456mg/l
물리적 상태
Crystalline Solid
산도 계수 (pKa)
15.30±0.60(Predicted)
색상
Colorless to white
수용성
insoluble
Merck
14,5837
JECFA Number
427
BRN
3194263
CAS 데이터베이스
89-78-1(CAS DataBase Reference)
NIST
DL-Menthol(89-78-1)
EPA
(1R,2S,5R)-Menthol (89-78-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,Xi
위험 카페고리 넘버 37/38-41-36/37/38
안전지침서 36/37/39-24/25-36-26-39
유엔번호(UN No.) UN 1888 6.1/PG 3
WGK 독일 2
RTECS 번호 OT0350000
자연 발화 온도 405 °C
TSCA Yes
HS 번호 29061100
독성 LD50 orally in rats: 3180 mg/kg (Jenner)
기존화학 물질 KE-24408
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H318 눈에 심한 손상을 일으킴 심한 눈 손상 또는 자극성 물질 구분 1 위험 P280, P305+P351+P338, P310
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.

멘톨 MSDS


p-Menthan-3-ol

멘톨 C화학적 특성, 용도, 생산

물성

시원한 청량감을 주는 휘발성 성분으로서, 박하속(민트) 식물들에 다량 함유되어 있다. 특유의 청량감 때문에 향신료로 많이 사용되며, 사탕이나 음료 등에 첨가되기도 한다.

개요

녹는점 43℃, 끓는점 216.5℃이지만 상온에서 쉽게 승화한다. 육각형의 침상(針狀) 또는 프리즘 모양의 결정이다. 물에 약간 녹고 알코올에 녹는다. 멘톨의 제조법에서 천연물로서는 우선 박하유를 추출하고, 이것을 냉각하여 거친 결정으로 만들고 재결정하여 정제한다. 또한 합성할 때는 멘톤·프레곤·피페리톤·티몰·이소프레골 등 케톤의 수소첨가를 한다.

개요

Menthol has a mint-like odor and a fresh, cooling taste. It may be prepared by hydrogenation of thymol.

화학적 성질

Menthol has a peppermint-like odor and exerts a cooling sensation when applied to skin and mucosal surfaces. Menthol is a monocyclic terpene alcohol with three asymmetric carbon atoms in its cyclohexane ring resulting in (–) and (+) menthol, neomen thol, isomenthol and neoisomenthol. (–)-Menthol is the isomer that occurs most widely in nature and is the one commonly identified as menthol.

화학적 성질

colorless to white crystalline solid

물리적 성질

Appearance: colorless or white acicular prismatic crystals or white crystalline powder. Solubility: easily dissolved in ethanol, chloroform, ether, liquid paraffin, or volatile oil and soluble in water. Odor: a cool, refreshing, and pleasant mint aroma, sweet odor, and taste cool early after burning. Boiling point: 212?°C. Melting point: 41–43?°C. Specific optical rotation: ?49 to ?50°.

출처

Reported found in peppermint and other mint oils (e.g., M. arvensis), lemon peel oil, cranberry, pineapple, cab bage, thymus, egg, rum, cocoa, tea, honey, avocado, coriander, mango, rice, litchi, dill herb, calamus, juniper berries, fennel, buchu oil, clam and Roman chamomile oil, Mentha species.

역사

In the world of aromatic chemicals, menthol is often described as a unique source of skin and mucous membranes. Menthol is mainly extracted from natural plants. The vast majority of natural menthol in the global market is extracted from numerous Asian mint. In 2006, the world’s natural menthol production is 12,800?tons or more. However, due to various factors, the production of natural menthol is becoming less and less. Since the 1960s, Japan, Germany, and other countries had developed the synthetic menthol products. In 1974 the German company Symrise and Japan Takasago Fluidic Systems company launched chemical synthesis of menthol. At present, attention has been paid to the study of menthol analogy substances and the effect of the changes of molecular structure on the aroma and cool sensation. Some studies have shown that hydroxyl groups located in the branched or 1, 4 chain cannot show a sense of cool. The researchers believed that menthol analogy substances with optical activity should be able to show different, surprising cooling effect, and the structure of hydroxyl alkyl groups is the key point to have a cooling effect. The Japanese chemist Ryoji Noyo and his colleagues found that in BINAP and rhodium complexes as catalysts for asymmetric hydrogenation reaction, the synthesis of menthol is very effective. Because of the contribution of asymmetric organic synthesis, they won the 2001 Nobel Prize in Chemistry.

용도

A chemical which triggers cold-sensitive TRPM8 receptors in the skin neurons in vitro.

용도

In liqueurs, confectionery, perfumery, cigarettes, cough drops, and nasal inhalers.

Indications

For external application, it is applied locally and often used to relieve pain and itching. A nasal drip is used in the head cold. Inhalation or spray is used for sore throat. Oral administration can promote digestion.

제조 방법

By hydrogenation of thymol.

Aroma threshold values

Detection: 950 ppb to 2.5 ppm; aroma characteristics at 1.0%: cooling menthol with a penetrating minty eucalyptus note.

Taste threshold values

Taste characteristics at 25 ppm: cooling, camphoreous, minty with a clean eucalyptus note.

일반 설명

White crystalline solid with a peppermint odor and taste.

공기와 물의 반응

Insoluble in water.

반응 프로필

DL-Menthol is incompatible with butyl chloral hydrate, camphor, phenol, chloral hydrate, Exalgine, betanaphthol, resorcinol or thymol in triturations; potassium permanganate, chromium trioxide and pyrogallol. DL-Menthol is also incompatible with strong oxidizers.

위험도

Irritant to mucous membranes on inhalation.

화재위험

DL-Menthol is combustible.

Pharmacology

Menthol has a wide range of pharmacological effects. Menthol can stimulate the nerve endings of skin and slowly penetrate into the skin, resulting in prolonged congestion and reflex caused by deep vascular changes, adjusting the vascular function, and achieving therapeutic effects in topical application. Topical application of compound has anti-inflammatory, analgesic, and anesthetic effects.
In respiratory system: For treatment of bronchitis, it could reduce the respiratory tract foam sputum and increase the effective ventilation cavity road. For treatment of rhinitis and laryngitis, it exerts mitigation by promoting secretion and diluting viscous mucus.
In digestive system: Menthol showed the powerful effect on bile.
In central nervous system: A small amount of peppermint can stimulate the central nervous system through the peripheral nerve to expand the skin capillaries, promote the secretion of sweat glands, increase heat dissipation, and show sweating antipyretic effect.
In addition, menthol has penetration-enhancing effect on many kinds of drugs; the mechanism is related to the changes of the ultrastructure of the skin, which is expected to be widely used in transdermal drug delivery agents. In vitro experiments, it had strong antibacterial activity against Staphylococcus aureus and Bacillus proteus. Recently, British scientists found that mint leaves can prevent cancer lesions in the blood vessel growth to decrease blood supply for, showing a certain anti-tumor effect

Clinical Use

It can be clinically used to assist anesthesia, postoperative analgesia, intercostal nerve block, trigeminal nerve block, occipital nerve block, and so on. When applied locally, it can promote blood circulation, diminish inflammation, relieve itching, relieve pain, relieve edema, and so on.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. A severe eye irritant. Incompatible with phenol, p-naphthol, resorcinol or thymol in trituration, potassium permanganate, chromium trioxide, pyrogallol. Combustible liquid. \When heated to decomposition it emits acrid smoke and irritating fumes.

멘톨 준비 용품 및 원자재

원자재

준비 용품


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