Aprepitant
|
|
Aprepitant 속성
- 녹는점
- 244-246°C
- 알파
- D25 +69° (c = 1.00 in methanol)
- 밀도
- 1.51±0.1 g/cm3(Predicted)
- 저장 조건
- Sealed in dry,2-8°C
- 용해도
- DMSO에 용해됨(>25mg/ml)
- 산도 계수 (pKa)
- 8.06±0.20(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
- optical activity
- [α]/D +61 to +71°, c = 1.0 in methanol
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- CAS 데이터베이스
- 170729-80-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
HS 번호 | 2934990002 |
---|
Aprepitant C화학적 특성, 용도, 생산
개요
Aprepitant is an antiemetic chemical compound that belongs to “substance P” antagonists (SPA) with its effect being blocking the neurokinin 1(Nk1) receptor. It is used for the prevention of acute and delayedchemotherapy-induced nausea and vomiting(CINV) and for prevention ofpostoperative nausea and vomiting. It can also be used for the treatment of cyclic vomiting syndrome and late-stage chemotherapy induced vomiting occurring during cancer treatment. Aprepitant alleviates the case of vomiting in patients through balking the signals released by Nk1 receptors. Nk1 is a G-protein-coupled receptor with its ligand being substance P (SP). The high concentration of SP is required for the vomiting reflex. Aprepitant blocks the process of SP-NK1 signaling in activating the vomiting reflex.화학적 성질
Off-White to Light Yellow Cyrstalline Solid용도
A novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.정의
ChEBI: A morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/ eurokinin 1 (NK1) receptors.참고 문헌
Curran, Monique P., and D. M. Robinson. "Aprepitant."Drugs69.13(2009):1853-1878.Sant P. Chawla M.D. † ‡, et al. "Establishing the dose of the oral NK 1, antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting." Cancer 97.9(2003):2290-2300.
Warr, D. G., et al. "Efficacy and tolerability of aprepitant for the prevention of chemotherapy-induced nausea and vomiting in patients with breast cancer after moderately emetogenic chemotherapy." Journal of Clinical Oncology Official Journal of the American Society of Clinical Oncology23.12(2005):2822-30.
https://en.wikipedia.org/wiki/Aprepitant
Aprepitant 준비 용품 및 원자재
원자재
준비 용품
Aprepitant 공급 업체
글로벌( 606)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 |
marketing1@neostarunited.com | China | 8350 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5960 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2504 | 58 |
Wuhan Quanjinci New Material Co.,Ltd. | +8615271838296 |
kyra@quanjinci.com | China | 1532 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Nanjing Gold Pharmaceutical Technology Co. Ltd. | 025-84209270 15906146951 |
CHINA | 115 | 55 | |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21703 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9359 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
Aprepitant 관련 검색:
메틸트리페닐포스포늄브로마이드 디클로로메틸페닐실란 디메트모르프 디페닐에테르 페닐초산
Ethoxymethylenemalononitrile
PHENYL VALERATE
Moroxydine
Moroxydine hydrochloride
Aprepitant iMpurity A
PHENYL RESIN
Aprepitant-d4
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
(S)-3-phenylmorpholine
2-(R)-[1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenylmorpholine[Aprepitant-M2]
1,2-Dihydro-3H-1,2,4-triazol-3-one
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine hydrochloride
Aprepitant 13C2, D2 (Major)