CINNAMYCIN
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CINNAMYCIN 속성
- 밀도
- 1.59±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- 에 용해됨 아세토니트릴: 물: 5mg/mL
- 산도 계수 (pKa)
- 3.15±0.11(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 갈색
안전
안전지침서 | 22-24/25 | ||
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WGK 독일 | 3 | ||
RTECS 번호 | GE1745000 |
CINNAMYCIN C화학적 특성, 용도, 생산
용도
Cinnamycin (lanthiopeptin) is a high molecular weight tricyclic antibiotic produced by several species of Streptoverticillium. Cinnamycin is a potent indirect inhibitor of phospholipase A2, acting by specifically sequestering phosphatidylethanolamine (PE), a major component of the mammalian plasma cell membrane. Cinnamycin induces trans-bilayer phospholipid movement in cell membranes to expose internally bound PE. At high surface concentrations of PE, cinnamycin induces membrane re-organisation including membrane fusion and alteration of gross morphology.일반 설명
Cinnamycin is synthesized after proteolytic cleavage from core peptide and takes up a compact globular structure.Biochem/physiol Actions
Cinnamycin is a tetracyclic polypeptide antibiotic containing 19 amino acids. The polypeptide has the unusual amino acids threo-3-methyl-lanthionine, meso-lanthionine, lysinoalanine and 3-hydroxyaspartic acid. It is produced by Streptomyces cinnamoneus and belongs to the duramycin-type l antibiotics. Lantibiotics are synthesized in the ribosome and undergo extensive post-translational modifications to attain their active antimicrobial form. The unique receptor for Cinnamycin, phosphatidylethanolamine (PE), is located on the inner leaflet of the plasma membrane. Cinnamycin induces transbilayer lipid movement leading to the exposure of PE to the outer leaflet of the plasma membrane. The interaction of Cinnamycin with PE provides a tool for PE monitoring. Cinnamycin is active against Gram-positive rods such as Bacilli, Clostyridium and Mycobacterium, causing cell wall biosynthesis stress.Cinnamycin, like other lantibiotics, was also reported to inhibit phospholipase A2 (PLA2). It was suggested as an alternative treatment for atherosclerosis through its ability to inhibit PLA2 by binding to its substrate PE. Moreover, Cinnamycin was found to inhibit Herpes simplex virus (HSV-1) activity.CINNAMYCIN 준비 용품 및 원자재
원자재
준비 용품
CINNAMYCIN 공급 업체
글로벌( 21)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
BOC Sciences | +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 |
isunpharm@qq.com | China | 4428 | 55 |
Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9709 | 58 |
Lynnchem | 86-(0)29-85992781 17792393971 |
info@lynnchem.com | China | 4587 | 58 |
Novachemistry | 44-20819178-90 02081917890 |
info@novachemistry.com | United Kingdom | 4381 | 58 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 |
sales@rrkchem.com | China | 55717 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11289 | 58 |
Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 |
sales@mitachieve.com | China | 8864 | 58 |
Energy Chemical | 021-58432009 400-005-6266 |
marketing1@energy-chemical.com | China | 44894 | 58 |
CINNAMYCIN 관련 검색:
디스프로슘 트리(2,2,6,6-테트라메틸-3,5-헵탄디오네이트) 아세틸아세토산 제2철 알루미늄 아세틸아세토네이트 아세틸아세톤산 구리 코발트(II) 아세틸아세토네이트 하이드레이트 실버 아세틸아세토네이트
Ethyl isocyanoacetate
SALCOMINE
TERT-BUTYL ISOCYANIDE
Benzyl isocyanide
METHYL ISOCYANOACETATE
N-BUTYLISOCYANIDE
PHENYLSELENOL
1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
Tosylmethyl isocyanide
TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
Tris(2,4-pentanedionato)chroMiuM(III)