Ciclopirox

Ciclopirox 구조식 이미지
카스 번호:
29342-05-0
상품명:
Ciclopirox
동의어(영문):
Penlac;6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one;gopmx;geprox;Loprox;HOE296b;Mycoster;Brumixol;Dafnegin;Cidochem
CBNumber:
CB7673863
분자식:
C12H17NO2
포뮬러 무게:
207.27
MOL 파일:
29342-05-0.mol
MSDS 파일:
SDS

Ciclopirox 속성

녹는점
1440C
끓는 점
350.0±25.0 °C(Predicted)
밀도
1.193±0.06 g/cm3(Predicted)
저장 조건
Keep in dark place,Sealed in dry,Room Temperature
용해도
물에 약간 용해되고 무수 에탄올과 염화메틸렌에 잘 용해됩니다.
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
6.25±0.58(Predicted)
색상
회백색
CAS 데이터베이스
29342-05-0(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
유엔번호(UN No.) UN 3077 9 / PGIII
HS 번호 2933790002
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P312 삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
0
3 0

Ciclopirox MSDS


6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone

Ciclopirox C화학적 특성, 용도, 생산

화학적 성질

White or Light-Yellow Powder

용도

Ciclopirox (Penlac) is a synthetic antifungal agent. Ciclopirox (Penlac) is used for topical dermatologic treatment of superficial mycoses. Ciclopirox (Penlac) is most useful against Tinea versicolor. [1] In a study conducted to further elucidate ciclopir

정의

ChEBI: A cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and cyclohexyl groups, repectively. A broad spectrum antigfungal agent, it also exhibits antibacterial acti ity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin and nail infections.

Mechanism of action

Ciclopirox has a unique mechanism of action through chelation of polyvalent cations, such as Fe3+, which causes inhibition of a number of metal-dependent enzymes within the fungal cell.

Mechanism of action

Ciclopirox is a substituted pyridione derivative. Experiments show that the mechanism of action involves a disruption of transport mechanisms into the cell plasma, especially the uptake of leucine. Further, the uptake of other amino acids such as phenylalanine and lysine, as well as the uptake of potassium and phosphate ions is impaired. This all probably involves a change in membrane permeability, as reported for some other antimycotics, although ciclopirox does not show lytic activity. Consecutively, the substance significantly reduces fungal growth rates.

Clinical Use

Ciclopirox is a hydroxylated pyridinone that is employed for superficial dermatophytic infections, principally onychomycosis.

Ciclopirox 준비 용품 및 원자재

원자재

준비 용품


Ciclopirox 공급 업체

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