Ticlopidine

Ticlopidine 구조식 이미지
카스 번호:
55142-85-3
상품명:
Ticlopidine
동의어(영문):
pcr5332;PCR 5332;Ticlosin;Anagregal;Caudaline;TICIOPIDINE;TICLOPIDINE;5-(2-Chlorobenzyl);Ticlopidine USP/EP/BP;Ticlopidine hydrochloride CRS
CBNumber:
CB7674370
분자식:
C14H14ClNS
포뮬러 무게:
263.79
MOL 파일:
55142-85-3.mol
MSDS 파일:
SDS

Ticlopidine 속성

녹는점
210-212 °C
끓는 점
117-120 °C(Press: 0.5 Torr)
밀도
1.273±0.06 g/cm3(Predicted)
저장 조건
2-8°C(protect from light)
용해도
클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
7.10±0.20(Predicted)
색상
황백색에서 연한 노란색
CAS 데이터베이스
55142-85-3(CAS DataBase Reference)
NIST
Thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-(55142-85-3)
EPA
Thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro- (55142-85-3)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
기존화학 물질 KE-05853
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352 피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P332+P313 피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P337+P313 눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.

Ticlopidine C화학적 특성, 용도, 생산

용도

Ticlopidine suppresses aggregation of thrombocytes and possesses antiaggregant activity. It is believed that its action is connected to its effect on thrombocyte membranes and the reduction in quantity of released adenosine diphosphate and serotonin, which facilitate aggregation of thrombocytes. In wide-ranging clinical trials, ticlopidine presented a number of advantages compared to aspirin.

정의

ChEBI: A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.

World Health Organization (WHO)

Ticlopidine, an inhibitor of platelet aggregation, was introduced in 1978 for use as an antithrombotic agent. By 1982 its use had been associated with cases of agranulocytosis, severe leucopenia and impaired haemostasis. The drug remains available in most countries in which it was approved with appropriate warnings in the product information.

일반 설명

Ticlopidine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno [3,2-c]pyridine hydrochloride(Ticlid), is useful in reducing cardiac events in patients withunstable angina and cerebrovascular events in secondaryprevention of stroke. It belongs to the thienopyridine classand facilitated the development of clopidogrel. One of thedrawbacks to this agent is its side effect profile, whichincludes neutropenia, and patients receiving this antithromboticshould have their blood levels monitored. Its mechanismof action is similar to that of clopidogrel, in that itinhibits the purinergic receptors on platelets.

Ticlopidine 준비 용품 및 원자재

원자재

준비 용품


Ticlopidine 공급 업체

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