Glucocorticoid. Beclomethasone is used in chronic asthma and allergic rhinitis. Antiallergic, antiasthmatic (inhalant). Anti-inflammatory (topical).
정의
ChEBI: A 17alpha-hydroxy steroid that is prednisolone in which the hydrogens at the 9alpha and 16beta positions are substituted by a chlorine and a methyl group, respectively.
Biological Functions
The topical anti-inflammatory potency for beclomethasone dipropionate (BDP) is approximately 5,000 times greater than hydrocortisone, 500 times greater than
betamethasone or dexamethasone, and approximately five times greater than fluocinolone acetonide or
triamcinolone acetonide, as measured by vasoconstrictor assay.
Clinical Use
Beclomethasone, a 9α-chloro analogue of betamethasone, is a potent glucocorticoid with
approximately half the potency of its fluoro analogue. It is used topically as its dipropionate derivative in
inhalation aerosol therapy for asthma and rhinitis but not for
treatment of steroid-responsive dermatoses.
