2-클로로니코틴산
|
|
2-클로로니코틴산 속성
- 녹는점
- 176-178 °C (dec.)(lit.)
- 끓는 점
- 316.8±22.0 °C(Predicted)
- 밀도
- 1.470±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO, 에틸아세테이트(약간 용해됨)
- 산도 계수 (pKa)
- 2.07±0.25(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 크림색으로
- BRN
- 119023
- InChI
- InChI=1S/C6H4ClNO2/c7-5-4(6(9)10)2-1-3-8-5/h1-3H,(H,9,10)
- InChIKey
- IBRSSZOHCGUTHI-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC=C1C(O)=O
- LogP
- 0.988
- CAS 데이터베이스
- 2942-59-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 22-24/25-37/39-26-36 | ||
| WGK 독일 | 3 | ||
| TSCA | T | ||
| 위험 등급 | IRRITANT | ||
| HS 번호 | 29333999 | ||
| 기존화학 물질 | KE-05892 |
2-클로로니코틴산 C화학적 특성, 용도, 생산
화학적 성질
white to cream powder. MP>175°C (decomposition), insoluble in water, soluble in organic solvents such as benzene and toluene.용도
2-Chloronicotinic Acid is used in the preparation of 4-thiazolidinone derivatives and Schiff bases displaying antimicrobial activity.제조 방법
Chloronicotinic acid was synthesized from nicotinic acid by oxidation by H2O2 and then chlorinationby POCl3 and PCl5 in a yield of 87.5%.Synthesis of 2-chloronicotinic acid: Pour chlorine gas into the mixed solution of phosphorus oxychloride and phosphorus trichloride, control the temperature at about 60°C, until the remaining chlorine gas escapes, cool and add nicotinic acid N-oxide in batches, and heat the mixed solution. The reaction was carried out at 100-105°C for 1-1.5 h, and the reaction mixture was stirred for 30 min after the reaction mixture was transparent, and phosphorus oxychloride was removed under reduced pressure. The obtained residue was cooled to room temperature, and water was added to obtain the finished product of 2-chloronicotinic acid.
2-클로로니코틴산 준비 용품 및 원자재
원자재
2-Chloro-3-picoline
β-피콜린
다이아이소프로필아민
2-chloro-3-trichloromethylpyridine
2-Chloro-5-methylpyridine
Nicotinic acid N-oxide
준비 용품
2-클로로니코틴산 공급 업체
글로벌( 908)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| CD Chemical Group Limited | +8615986615575 |
info@codchem.com | China | 20356 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |
| Nanjing Hengbei Chemicals Co., Ltd. | +86-25-58393656 |
sales@hengbeichem.cn | China | 6856 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Changzhou Jiuwu Chemical co., Ltd. | +86-0519-85121086 +8613775162768 |
info@jiuwuchem.cn | China | 75 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7786 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 |
sales@frappschem.com | China | 885 | 50 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |