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4,4'-메틸렌디아닐린

4,4'-메틸렌디아닐린
4,4'-메틸렌디아닐린 구조식 이미지
카스 번호:
101-77-9
한글명:
4,4'-메틸렌디아닐린
동의어(한글):
4,4'-다이아미노다이페닐메테인;4,4""-메틸렌디아닐린;4,4'-메틸렌디아닐린;4,4'-메틸레네다이아닐린;4-(4-아미노벤질)아닐린;4-(P-아미노벤질)아닐린;4,4-다이아미노다이페닐메탄;4,4'-디아미노디페닐메탄;4,4'-디페닐메탄디아민;4,4'-메틸렌다이벤젠아민;4,4'-메틸렌다이아닐린;4,4'-메틸렌비스(벤젠아민);4,4'-메틸렌비스(아닐린);4,4'-메틸렌비스벤젠아민;4,4'-메틸렌비스-벤젠아민;p,p'-디아미노페닐메탄;P,P'-메틸렌디아닐린;다이아닐리노메탄;디아닐린메탄;디아미노디페닐메탄
상품명:
4,4'-Methylenedianiline
동의어(영문):
MDA;DADPM;ht972;Tonox;HT 972;Tonox R;MDA-100;Tonox 22;Curithane;sumicurem
CBNumber:
CB7718182
분자식:
C13H14N2
포뮬러 무게:
198.26
MOL 파일:
101-77-9.mol

4,4'-메틸렌디아닐린 속성

녹는점
89-91 °C(lit.)
끓는 점
242 °C2 mm Hg(lit.)
밀도
1.15
굴절률
1.5014 (estimate)
인화점
430 °F
용해도
water: soluble
물리적 상태
neat
산도 계수 (pKa)
5.32±0.25(Predicted)
수용성
Slightly soluble. <0.1 g/100 mL at 19 ºC
Merck
14,2980
BRN
474706
CAS 데이터베이스
101-77-9(CAS DataBase Reference)
NIST
Benzenamine, 4,4'-methylenebis-(101-77-9)
IARC
2B (Vol. 39, Sup 7) 1987
EPA
4,4'-Methylenedianiline (101-77-9)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,N
위험 카페고리 넘버 45-39/23/24/25-43-48/20/21/22-51/53-68
안전지침서 53-45-61
유엔번호(UN No.) UN 2651 6.1/PG 3
WGK 독일 3
RTECS 번호 BY5425000
TSCA Yes
위험 등급 6.1
포장분류 III
HS 번호 29215900
유해 물질 데이터 101-77-9(Hazardous Substances Data)
독성 LD50 oral in rabbit: 620mg/kg
기존화학 물질 KE-23803
유해화학물질 필터링 2014-1-699
중점관리물질 필터링 별표1-51
함량 및 규제정보 물질구분: 유독물질; 혼합물(제품)함량정보: 4,4'-메틸렌디아닐린 및 이를 0.1% 이상 함유한 혼합물
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H341 유전적인 결함을 일으킬 것으로 의심됨 (노출되어도 생식세포 유전독성을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 생식세포 변이원성 물질 구분 2 경고 P201,P202, P281, P308+P313, P405,P501
H350 암을 일으킬 수 있음 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 1A, 1B 위험
H370 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재) 특정 표적장기 독성 - 1회 노출 구분 1 위험 P260, P264, P270, P307+P311, P321,P405, P501
H373 장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킬 수 있음 특정 표적장기 독성 - 반복 노출 구분 2 경고 P260, P314, P501
H401 수생생물에 유독함 수생 환경유해성 물질 - 급성 구분 2 P273, P501
H411 장기적 영향에 의해 수생생물에 유독함 수생 환경유해성 물질 - 만성 구분 2
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.
NFPA 704
1
3 0

4,4'-메틸렌디아닐린 MSDS


4,4'-Methylenebisbenzeneamine

4,4'-메틸렌디아닐린 C화학적 특성, 용도, 생산

개요

Diaminodiphenylmethane is an aromatic diamine used as a curing agent in epoxy res ins of t11e bisphenol A type, as in the production of plastics, isocyanates, adhesives, elastomers, polyuret11ane (elastic and rigid foams, paints, lacquers, adhesives, binding agents, synt11etics rubbers, and elastomeric fibers) and butyl rubber. Diaminodiphenylmet11ane is also a by-product of azo dyes. It is also possibly formed by hydrolysis of diphenylmethane-4A'-diisocyanate.

화학적 성질

4,4’-Diaminodiphenylmethane is a pale yellow crystalline solid (turns light brown on contact with air) with a faint amine-like odor.

화학적 성질

white to yellow or beige flakes or crystals

용도

4,4'-methylenedianiline be used as organic intermediates. Mainly used for the synthesis of polyimide and as curing agent of epoxy resin.

용도

As chemical intermediate in production of isocyanates and polyisocyantes for preparation of polyurethane foams, Spandex fibers; as curing agent for epoxy resins and urethane elastomers; in production of polyamides; in the determination of tungsten and sulfates; in preparation of azo dyes; as corrosion inhibitor.

용도

4,4'-Diaminodiphenyl-methane is used in the determination of tungsten and sulfates; in the preparation of azo dyes; cross-linking agent for epoxy resins; in the preparation of isocyanates and polyisocyanates; in the rubber industry as a curative for neoprene, as an anti-frosting agent (antioxidant) in footwear; raw material in preparation of poly(amide-imide) resins (used in magnet-wire enamels); curing agent for epoxy res ins and urethane elastomers; corrosion inhibitor; rubber additive (accelerator, antidegradant, retarder) in tires and heavy rubber products; in adhesives and glues, laminates, paints and inks, PVC products, handbags, eyeglass frames, plastic jewelry, electric encapsulators, surface coatings, spandex clothing, hairnets, eyelash curlers, earphones, balls, shoe soles, face masks.

정의

ChEBI: An aromatic amine that is diphenylmethane substituted at the 4-position of each benzene ring by an amino group.

일반 설명

A tan flake or lump solid with a faint fishlike odor. May be toxic by inhalation or ingestion, and may be irritating to skin. Insoluble in water.

공기와 물의 반응

Oxidizes slowly in air in a reaction catalyzed by light. Somewhat hygroscopic. Insoluble in water.

반응 프로필

4,4'-Methylenedianiline polymerizes if heated above 257° F. Incompatible with strong oxidizing agents. 4,4'-Methylenedianiline is also incompatible with acids. Catalyzes isocyanate-alcohol and epoxide reactions. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

건강위험

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

화재위험

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Safety Profile

Confirmed carcinogen with experimental tumorigenic data. Human poison by ingestion. Poison by subcutaneous and intraperitoneal routes. Human systemic effects by ingestion: rigidity, jaundice, other liver changes. An eye irritant. Mutation data reported. It is not rapidly absorbed through the skin. Combustible when exposed to heat or flame. When heated to decomposition it emits highly toxic fumes of aniline and NOx.

잠재적 노출

Used as an intermediate and as a curing agent. Approximately 99% of the DDM produced is con- sumed in its crude form (occasionally containing not more than 50% DDM and ply-DDM) at its production site by reac- tion with phosgene in the preparation of isocyanates and poly- isocyanates. These isocyanates and polyisocyanates are employed in the manufacture of rigid polyurethane foams which find application as thermal insulation. Polyisocyanates are also used in the preparation of the semiflexible polyure- thane foams used for automotive safety cushioning. DDM is also used as: an epoxy hardening agent; a raw material in the production of polyurethane elastomers; in the rubber industry as a curative for Neoprene and as an antifrosting agent (anti- oxidant) in footwear; a raw material in the production of Quana nylon; and a raw material in the preparation of poly (amide-imide) resins (used in magnet wire enamels).

Carcinogenicity

4,4′-Methylenedianiline and its dihydrochloride salt are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals.

환경귀착

MDA is a pale brown crystalline powder with a faint aminelike odor. Exposure to air and light results in polymerization and oxidation of MDA. When heated, MDA produces toxic fumes of aniline and nitrogen oxides.
Most MDA enters the environment when it is produced or used to make other compounds. Forty-five percent of the produced compound is released to deep soil, 52.6% to the air, and 2.4% to land and water. Once in the environment, it will be mainly present as tiny particles in the air and it is removed from the atmosphere by dry deposition, rain, and snow scavenging. A small amount is transformed by reaction with hydroxyl radicals. In water, most of MDA will attach to particles and sediments, and will eventually settle to the bottom.
The estimated half-life of biodegradation in surface water, groundwater, and soil is 1–7 days, 2–14 days, and 1–7 days, respectively. With respect to aquatic ecosystems, bioconcentration factor values of 3.0–14 suggest that bioconcentration is low, in addition this compound does not tend to build up in the food chain. When released to soil, it is expected to have slight to no mobility. Similarly, volatilization from both moist and dry soil surfaces is not expected to be important.

운송 방법

UN2651 4,40 -Diaminodiphenyl methane, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Crystallise the amine from water, 95% EtOH or *benzene. [Beilstein 13 IV 390.]

Toxicity evaluation

Currently, the mechanism of action is not completely understood and has been mostly assessed from information on structurally similar compounds. Many of the toxic properties of MDA have been attributed to metabolic intermediates, as these compounds are metabolically activated by N-oxidation to metabolites, such as N-hydroxymethylenedianiline, that react with DNA, RNA, and proteins.
Different studies suggest that both liver and thyroid are targets for MDA toxicity in humans and animals. Liver toxicity has been linked to impair mitochondrial function and structure, apoptosis, and increased oxidative stress. It may be caused by a reactive electrophile formed during metabolism since liver has the enzymatic routes necessary for such activation. Experimental studies indicate that biliary epithelial cells are damaged earlier than parenchymal cells and bile is a major route of exposure to MDA. The mechanism of thyroid toxicity has not yet been resolved. It has been observed that MDA exposure can induce a slight decrease in thyroid hormones in rats, thus triggering secretion of thyroid-stimulating hormone (TSH), which induced thyroid hyperplasia. Some of the induced adverse effects observed after MDA exposure (e.g., reduced food consumption, lower body weight gain, and effects on red cells, lymphocytes, and clotting parameters) could be explained as secondary responses.
MDA is carcinogenic to animals. The mechanism of liver or thyroid tumor development remains unclear. Even if cell injury may give indications of a nongenotoxic mechanism, it remains still unproved, and there are also positive genotoxic data in vitro and in vivo which indicate that a genotoxic mechanism may be related to the formation of a reactive metabolic intermediate cannot be excluded. Regarding thyroid cancer, hypersecretion of TSH may have a contribution to tumor formation.

비 호환성

Dust forms and explosive mixture with air. May polymerize in temperatures .125℃ . A weak base. Incompatible with strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong acids. Flammable gas- eous hydrogen may be generated in combination with strong reducing agents, such as hydrides .

폐기물 처리

Controlled incineration (oxides of nitrogen are removed from the effluent gas by scrubbers and/or thermal devices).

4,4'-메틸렌디아닐린 준비 용품 및 원자재

원자재

준비 용품


4,4'-메틸렌디아닐린 공급 업체

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Chengdu Yuanda Chemical Co., Ltd
86-28-85356300 / 18980937689
86-28-85356300 sales@ydachem.com CHINA 94 58
Shanghai Daeyeon Chemicals Co., Ltd
+8615900664856 +86-021-6447-8606
daeyeon001@vip.163.com China 3082 58
Dayang Chem (Hangzhou) Co.,Ltd.
17705817739 +86-571-88938639
+86-571-88938652,+86-571- 88492614 info@dycnchem.com CHINA 52932 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd.
0431-80514535 13634302652
0431-88607838 Extension@chemextension.com CHINA 967 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5450 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58

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