싸이오아세트아마이드 C화학적 특성, 용도, 생산
개요
Thioacetamide (TAA) is not known to occur in nature. It is
prepared by heating ammonium acetate and aluminum sulfide.
화학적 성질
Thioacetamide is combustible, crystalline compound. Slight mercaptan odor.
용도
Thioacetamide is a carcinogen, a hepatotoxicant. Thioacetamide induces acute chronic liver injury through the activation of protein synthesis of RNA, DNA, and gamma-glutamyl transpeptitase. Thioacetamide has been used in the synthesis of [email?protected] nano-array core-shell structure.
정의
ChEBI: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
일반 설명
White crystals with a mercaptan odor.
공기와 물의 반응
Slightly water soluble.
반응 프로필
Thioacetamide reacts with aqueous acid to generate hydrogen sulfide. Forms addition compounds and sulfides with salts of heavy metals. Hydrolyzed by acids or bases .
위험도
Toxic by ingestion and inhalation, a possible
carcinogen.
화재위험
Flash point data on Thioacetamide are not available; Thioacetamide is probably combustible.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic,
neoplas tigenic, tumorigenic, and teratogenic
data. Poison by ingestion and intraperitoneal
routes. Moderately toxic by subcutaneous
route. Human mutation data reported. An
experimental teratogen. Experimental
reproductive effects. Exposure has caused
liver damage. When heated to
decomposition it emits very toxic fumes of
NOx and SOx. See also SULFIDES and
MERCAPTANS.
잠재적 노출
Thioacetamide is used as a replacement for hydrogen sulfide in qualitative analyses. Thioacetamide has been used as an organic solvent in the leather, textile, and paper industries; as an accelerator in the vulcanization of buna rubber; and as a stabilizer of motor fuel.
Carcinogenicity
Thioacetamide is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
환경귀착
TAA’s production and use as a substitute for hydrogen sulfide in
the laboratory may result in its release to the environment
through various waste streams. If released to air, TAA’s estimated
vapor pressure indicates that it will exist solely as a vapor
in the ambient atmosphere. Vapor-phase TAA will be degraded
in the atmosphere by reaction with photochemically produced
hydroxyl radicals; the half-life for this reaction in air is estimated
to be 18 h. TAA was not biodegraded by activated sludge
after 5 days, and therefore may be resistant to biodegradation
in the environment. Hydrolysis is not expected since amides
hydrolyze very slowly under environmental conditions. An
estimated bioconcentration factor for TAA suggests that the
potential for bioconcentration in aquatic organisms is low. TAA
is expected to be highly mobile in soil, and to volatilize into the
atmosphere from moist soil surfaces. In an aquatic environment,
most of the substance will leave via volatilization and is
not expected to adsorb to solids.
운송 방법
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification Methods
Crystallise the amide from absolute diethyl ether or *benzene. Dry it at 70o in a vacuum and store it over P2O5 at 0o under nitrogen. (It develops an obnoxious odour on storage, and absorption at 269nm decreases, hence it should be freshly recrystallised before use). [Beilstein 2 IV 565.]
비 호환성
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
폐기물 처리
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Treatment in an incinerator, boiler or cement kiln.
싸이오아세트아마이드 준비 용품 및 원자재
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