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p-니트로페놀

p-니트로페놀
p-니트로페놀 구조식 이미지
카스 번호:
100-02-7
한글명:
p-니트로페놀
동의어(한글):
4-나이트로페놀;p-나이트로페놀;p-니트로페놀;나이트로페놀;4-하이드록시나이트로벤젠
상품명:
4-Nitrophenol
동의어(영문):
HONP;Niphen;NSC 1317;NCI-C55992;in methanoL;Nirtrphenol;4-Nitrofenol;p-Nitrofenol;4-Nitrophenol;4-nitro-pheno
CBNumber:
CB7852550
분자식:
C6H5NO3
포뮬러 무게:
139.11
MOL 파일:
100-02-7.mol

p-니트로페놀 속성

녹는점
112 °C
끓는 점
279 °C(lit.)
밀도
1,27 g/cm3
증기압
0.6 mm Hg ( 120 °C)
굴절률
1.5723 (estimate)
인화점
169 °C
저장 조건
Store in dark!
용해도
ethanol: soluble95%, clear, dark yellow (100 mg/mL)
물리적 상태
Crystalline Powder, Crystals and/or Chunks
산도 계수 (pKa)
7.15(at 25℃)
색상
Yellow to brown
Specific Gravity
1.479
냄새
Odorless
수소이온지수(pH)
4.4 (5g/l, H2O, 24℃)(anhydrous substance)
pH 범위
5.3(colorless)-7.6(Yellow)
수용성
1.6 g/100 mL (25 ºC)
최대 파장(λmax)
320nm, 405nm
감도
Light Sensitive
Merck
14,6620
BRN
1281877
Henry's Law Constant
1.63 x 10-7 at 5 °C (average derived from six field experiments, Lüttke and Levsen, 1997)
안정성
Stable. Incompatible with strong oxidizing agents, strong bases, organics, combustible material, reducing agents. Combustible.
주요 응용
Display device, solar cells, nanoparticles, electrolytic capacitors, lithographic printing plate, leak detection method, falsification-proof security paper, correction fluid, detergent, fertilizer, identifying fresh and stale rice, diapers, detecting lactic acid bacteria, drug delivery, evaluating dental caries activity
CAS 데이터베이스
100-02-7(CAS DataBase Reference)
NIST
Phenol, 4-nitro-(100-02-7)
EPA
p-Nitrophenol (100-02-7)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,T,F
위험 카페고리 넘버 20/21/22-33-39/23/24/25-23/24/25-11
안전지침서 28-28A-45-36/37-16-7
유엔번호(UN No.) UN 1663 6.1/PG 3
WGK 독일 2
RTECS 번호 SM2275000
F 고인화성물질 8
자연 발화 온도 541 °F
TSCA Yes
위험 등급 6.1
포장분류 III
HS 번호 29089000
유해 물질 데이터 100-02-7(Hazardous Substances Data)
독성 LD50 orally in mice, rats: 467, 616 mg/kg, K.C. Back et al., Reclassification of Materials Listed as Transportation Health Hazards (TSA-20-72-3; PB214-270, 1972)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 P264, P270, P301+P310, P321, P330,P405, P501
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H312 피부와 접촉하면 유해함 급성 독성 물질 - 경피 구분 4 경고 P280,P302+P352, P312, P322, P363,P501
H332 흡입하면 유해함 급성 독성 물질 흡입 구분 4 경고 P261, P271, P304+P340, P312
H370 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재) 특정 표적장기 독성 - 1회 노출 구분 1 위험 P260, P264, P270, P307+P311, P321,P405, P501
H373 장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킬 수 있음 특정 표적장기 독성 - 반복 노출 구분 2 경고 P260, P314, P501
예방조치문구:
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P311 의료기관(의사)의 진찰을 받으시오.
P321 (…) 처치를 하시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P403+P233 용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.
NFPA 704
1
3 2

p-니트로페놀 MSDS


4-Nitrophenol

p-니트로페놀 C화학적 특성, 용도, 생산

용도

여러 가지 중요한 유기화합물의 원료로 쓰이는 외에 지시약으로도 쓰이고, pH 5.6~7.5에서 무색에서 황색으로 변한다.

화학적 성질

Yellow to tan crystals or powder

용도

Used in the manufacturing of pharmaceuticals, fungicides, dyes.

용도

manufacture of pharmaceuticals, fungicides, dyes. Indicator in 0.1% alcohol solution. pH: 5.6 colorless, 7.6 yellow.

용도

4-Nitrophenol is used in dyestuff and pesticide synthesis, as a fungicide, bactericide, and wood preservative, as a chemical indicator, and as a substrate for experiments on cytochrome P450 2E1.

정의

ChEBI: A member of the class of 4-nitrophenols that is phenol in which the hydrogen that is para to the hydroxy group has been replaced by a nitro group.

일반 설명

A white to light yellow crystalline solid. Contact may severely irritate skin and eyes. Poisonous by ingestion and moderately toxic by skin contact.

공기와 물의 반응

Soluble in hot water and more dense than water.

반응 프로필

4-Nitrophenol is a slightly yellow, crystalline material, moderately toxic. Mixtures with diethyl phosphite may explode when heated. Decomposes exothermally, emits toxic fumes of oxides of nitrogen [Lewis, 3rd ed., 1993, p. 941]. Decomposes violently at 279°C and will burn even in absence of air [USCG, 1999]. Solid mixtures of the nitrophenol and potassium hydroxide (1:1.5 mol) readily deflagrate [Bretherick, 5th Ed., 1995].

위험도

Toxic by ingestion.

건강위험

Inhalation or ingestion causes headache, drowsiness, nausea, and blue color in lips, ears, and fingernails (cyanosis). Contact with eyes or skin causes irritation; can be absorbed through skin to give same symptoms as for inhalation.

Safety Profile

Poison by ingestion, subcutaneous, intraperitoneal, intravenous, and intramuscular routes. Moderately toxic by skin contact. Human mutation data reported. Its exothermic decomposition causes a dangerously fast pressure increase. Murtures with diethyl phosphite may explode when heated. When heated to decomposition it emits toxic fumes of NOx. See also other nitrophenol entries and NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.

환경귀착

Biological. Under anaerobic conditions, 4-nitrophenol may undergo nitroreduction producing 4- aminophenol (Kobayashi and Rittman, 1982). Estuarine sediment samples collected from the Mississippi River near Leeville, LA were used to study the mineralization of 4-nitrophenol under aerobic and anaerobic conditions. The rate of mineralization to carbon dioxide was found to be faster under aerobic conditions (1.04 x 10-3 μg/day/g dry sediment) than under anaerobic conditions (2.95 x 10-5 μg/day/g dry sediment) (Siragusa and DeLaune, 1986). In lake water samples collected from Beebe and Cayuga Lakes, Ithaca, NY, 4-nitrophenol at 50, 75, and 100 μg/L was not mineralized after 7 d. When the lake water samples were inoculated with the microorganism Corynebacterium sp., extensive mineralization was observed. However, at a concentration of 26 μg/L the extent of mineralization was much lower than at higher concentrations. The presence of a eucaryotic inhibitor (cycloheximide) also inhibited mineralization at the lower concentration but did not affect mineralization at the higher concentrations (Zaidi et al., 1989).
Surface Water. Photodegration half-lives of 5.7, 6.7, and 13.7 d were reported at pH values of 5, 7, and 9, respectively (Hustert et al., 1981).
Groundwater. Nielsen et al. (1996) studied the degradation of 4-nitrophenol in a shallow, glaciofluvial, unconfined sandy aquifer in Jutland, Denmark. As part of the in situ microcosm study, a cylinder that was open at the bottom and screened at the top was installed through a cased borehole approximately 5 m below grade. Five liters of water was aerated with atmospheric air to ensure aerobic conditions were maintained. Groundwater was analyzed weekly for approximately 3 months to determine 4-nitrophenol concentrations with time. The experimentally determined first-order biodegradation rate constant and corresponding half-life were 0.2/d and 3.47 d, respectively.
Photolytic. An aqueous solution containing 200 ppm 4-nitrophenol exposed to sunlight for 1–2 months yielded hydroquinone, 4-nitrocatechol, and an unidentified polymeric substance (Callahan et al., 1979). Under artificial sunlight, river water containing 2 to 5 ppm 4-nitrophenol photodegraded to produce trace amounts of 4-aminophenol (Mansour et al., 1989). A carbon dioxide yield of 39.5% was achieved when 4-nitrophenol adsorbed on silica gel was irradiated with light (λ >290 nm) for 17 h (Freitag et al., 1985).
Chemical/Physical. Wet oxidation of 4-nitrophenol at 320 °C yielded formic and acetic acids (Randall and Knopp, 1980). Wet oxidation of 4-nitrophenol at an elevated pressure and temperature gave the following products: acetone, acetaldehyde, formic, acetic, maleic, oxalic, and succinic acids (Keen and Baillod, 1985).

신진 대사 경로

4-[U-14C]Nitrophenol is conjugated as its b-glucoside (ca 22% of applied 14C) and gentiobioside, glc- b(126)-glc-b-4-nitrophenol (ca 64%), while about 7% of the parent remains unchanged in cell suspension cultures of Datura stramonium (L.). Gal-b-4-nitrophenol is found to be a minor metabolite.

Purification Methods

Crystallise 4-nitrophenol from water (which may be acidified, e.g. with N H2SO4 or 0.5N HCl), EtOH, aqueous MeOH, CHCl3, *benzene or pet ether, then dry it in vacuo over P2O5 at 25o. It can be sublimed at 60o/10-4mm. The 4-nitrobenzoate had m 159o (from EtOH). [Beilstein 6 IV 1279.]

p-니트로페놀 준비 용품 및 원자재

원자재

준비 용품


p-니트로페놀 공급 업체

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Nanjing XiZe Biotechnology CO., Ltd. 15250997978
025-58362220 sale@njxizebio.com; China 6509 55

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