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m-크레졸

m-크레졸
m-크레졸 구조식 이미지
카스 번호:
108-39-4
한글명:
m-크레졸
동의어(한글):
m-크레졸;1-히드록시-3-메틸벤젠;3-히드록시톨루엔;M-메틸페놀;M-옥시톨루엔;M-크레솔;M-크레시릴릭산;3-메틸페놀;3-크레솔;M-톨루올;M-히드록시톨루엔;메타크레졸퍼플수용액;크로톤알데히드(M-크레솔);1-옥시-3-메틸벤졸;1-하이드록시-3-메틸벤젠;1-하이드록시-3-메틸벤졸;3-하이드록시톨루엔;3-하이드록시톨루올;m-크레실산;m-하이드록시톨루엔
상품명:
m-Cresol
동의어(영문):
m-Cesol;M-CRESOL;m-Kresol;m-Toluol;3-Cresol;m-Cresole;FEMA 3530;2015-11-16;M-CresolGr;META-CRESOL
CBNumber:
CB7852747
분자식:
C7H8O
포뮬러 무게:
108.14
MOL 파일:
108-39-4.mol

m-크레졸 속성

녹는점
8-10 °C(lit.)
끓는 점
203 °C(lit.)
밀도
1.034 g/mL at 25 °C(lit.)
증기 밀도
3.72 (vs air)
증기압
<1 mm Hg ( 20 °C)
굴절률
n20/D 1.541(lit.)
FEMA
3530 | M-CRESOL
인화점
187 °F
저장 조건
Store below +30°C.
용해도
23.5g/l
산도 계수 (pKa)
10.01(at 25℃)
물리적 상태
Liquid
색상
Clear colorless to slight red
수소이온지수(pH)
5 (20g/l, H2O, 20℃)
폭발한계
1.06-1.35%, 150°F
Odor Threshold
0.0001ppm
수용성
20 g/L (20 ºC)
최대 파장(λmax)
273nm(lit.)
Merck
14,2579
JECFA Number
692
BRN
506719
안정성
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, strong acids, aluminium, aluminium alloys. Air and light sensitive. Hygroscopic.
CAS 데이터베이스
108-39-4(CAS DataBase Reference)
NIST
Phenol, 3-methyl-(108-39-4)
EPA
m-Cresol (108-39-4)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T
위험 카페고리 넘버 24/25-34-39/23/24/25-23/24/25
안전지침서 36/37/39-45-36/37
유엔번호(UN No.) UN 2076 6.1/PG 2
WGK 독일 1
RTECS 번호 GO6125000
F 고인화성물질 8
자연 발화 온도 626 °C
TSCA Yes
위험 등급 6.1
포장분류 II
HS 번호 29071200
유해 물질 데이터 108-39-4(Hazardous Substances Data)
독성 LD50 orally in rats: 2.02 g/kg (Deichmann, Witherup)
기존화학 물질 KE-24793
유해화학물질 필터링 97-1-268
사고대비 물질 필터링 27
함량 및 규제정보 물질구분: 유독물질; 혼합물(제품)함량정보: 크레졸 및 이를 5% 이상 함유한 혼합물
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H227 가연성 액체 인화성 액체 구분 4 경고 P210, P280, P370+P378, P403+P235,P501
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 P264, P270, P301+P310, P321, P330,P405, P501
H311 피부와 접촉하면 유독함 급성 독성 물질 - 경피 구분 3 위험 P280, P302+P352, P312, P322, P361,P363, P405, P501
H314 피부에 심한 화상과 눈에 손상을 일으킴 피부부식성 또는 자극성물질 구분 1A, B, C 위험 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 눈에 심한 손상을 일으킴 심한 눈 손상 또는 자극성 물질 구분 1 위험 P280, P305+P351+P338, P310
H351 암을 일으킬 것으로 의심됨 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
H370 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재) 특정 표적장기 독성 - 1회 노출 구분 1 위험 P260, P264, P270, P307+P311, P321,P405, P501
H372 장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴 특정 표적장기 독성 - 반복 노출 구분 1 위험 P260, P264, P270, P314, P501
H373 장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킬 수 있음 특정 표적장기 독성 - 반복 노출 구분 2 경고 P260, P314, P501
H401 수생생물에 유독함 수생 환경유해성 물질 - 급성 구분 2 P273, P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P310 즉시 의료기관(의사)의 진찰을 받으시오. 삼켰다면 즉시 의료기관(의사)의 도움을 받으시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P303+P361+P353 피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P307+P311 노출된 경우,독성 물질 센터 또는 의사에게 전화하기
P370+P378 화재 시 불을 끄기 위해 (Section 5. 폭발, 화재시 대처방법의 적절한 소화제)을(를) 사용하시오.
P405 밀봉하여 저장하시오.
P403+P233 용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.
P403+P235 환기가 잘 되는 곳에 보관하고 저온으로 유지하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
2
3 0

m-크레졸 MSDS


m-Cresol

m-크레졸 C화학적 특성, 용도, 생산

화학적 성질

colourless to light yellow liquid

화학적 성질

Cresol is a mixture of the three isomeric cresols, o-, m-, and p-cresol. Cresols are slightly soluble in water. m-Isomer: Colorless or yellow liquid with characteristic odor.

화학적 성질

m-Cresol has a dry, tarry, medicinal–leathery odor. m-Cresol and p-cresol very often occur together and are difficult to separate.

출처

Reported found in beer, coffee, egg, grape, Oriental tobacco, roasted barley, rum, sherry and whiskey.

용도

m-Cresol is used as a disinfectant and solvent. LysolTM disinfectant is a 50% (v/v) mixed-cresol isomer in a soap emulsion formed on mixing with water. The isomer m-cresol is an oily liquid with low volatility. Besides disinfection at solutions of 1–5%, the cresols are used in degreasing compounds, paintbrush cleaners, and additives in lubricating oils. Cresols were once widely used for disinfection of poultry houses, but this use has been discontinued because they cause respiratory problems and abdominal edema in young chicks. m-Cresol has been used in synthetic resins, explosives, petroleum, photographic, paint, and agricultural industries.

용도

m-Cresol is employed in the preparation of synthetic resins like phenol-formaldehyde resins, disinfectants, and photographic developers. It is used as industrial solvent for dissolving polymers such as polyaniline. It acts as a precursor to vitamin E and antiseptic amylmetacresol. It is used as insuline preservatives.

용도

Antiseptic; antimicrobial preservative.

정의

ChEBI: A cresol with the methyl substituent at position 3. It is a minor urinary metabolite of toluene.

생산 방법

The cresols (cresylic acids) are methyl phenols and generally appear as a mixture of isomers. m-Cresol is prepared from m-toluic acid or obtained from coal tar or petroleum (352, 355, 356). Crude cresol is obtained by distilling “gray phenic acid” at a temperature of ~180–201°C. The m-cresol may be separated from the crude or purified mixture by repeated fractional distillation in vacuo. It can also be prepared synthetically by diazotization of the specific toluidine or by fusion of the corresponding toluenesulfonic acid with sodium hydroxide.

제조 방법

One process involving butylation and separation and followed by dealkylation produces m-cresol and ditertiary butyl p-cresol. From m, p-cresol (which is the main product of the recovery process) pure m-cresol can be obtained by extraction.

Aroma threshold values

Aroma characteristics at 1.0%: phenolic, spicy eugenol-like, medicinal, smoky powdery with a leatherlike note.

Taste threshold values

Taste characteristics at 2 ppm: phenolic, smoky, balsamic, medicinal and spicy eugenol-like

일반 설명

Colorless liquid with a sweet tarry odor. Sinks and mixes slowly with water.

공기와 물의 반응

Water soluble.

반응 프로필

m-Cresol is sensitive to air, light and heat. m-Cresol is also hygroscopic. m-Cresol can react vigorously with strong oxidizers and strong bases. m-Cresol reacts violently with nitric acid, oleum, chlorosulfonic acid, metals and strong acids. If the water content is below approximately 0.3% and the temperature above 248° F, the corrosion of aluminum and its alloys may occur violently. m-Cresol will attack some forms of plastics, coatings and rubber.

위험도

Questionable carcinogen.

건강위험

INHALATION: Mucosal irritation and systemic poisoning EYES: Intense irritation and pain, swelling of conjunctiva, and corneal damage may occur. SKIN: Intense burning, loss of feeling, wrinkling, white discoloration, and softening. Gangrene may occur. INGESTION: Burning sensation in mouth and esophagus. Vomiting may result. Acute exposure by all routes may cause muscular weakness, gastroenteric disturbances, severe depression, collapse. Effects are primarily on CNS and edema of lungs. Injury of spleen and pancreas may occur.

색상 색인 번호

Metacresol is contained as a preservative in almost all human insulin. It has been reported as a cause of allergic reaction due to injected insulin.

Safety Profile

v Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by skin contact. Severe eye and skin irritant. An experimental teratogen. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic data. Flammable when exposed to heat or flame. Moderately explosive in the form of vapor when exposed to heat or flame. See also other cresol entries and PHENOL.

잠재적 노출

Cresol is used as a disinfectant and fumigant; as an ore flotation agent, and as an intermediate in the manufacture of chemicals, dyes, plastics, and antioxidants. A mixture of isomers is generally used; the concentrations of the components are determined by the source of the cresol.

Carcinogenicity

m-Cresol has induced a few papillomas but no carcinomas in tumor studies.

운송 방법

UN2076 Cresols, liquid, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 8-Corrosive material. UN3455 Cresols, solid, Hazard class: 6.1; Labels: 6.1- Poisonous materials, 8-Corrosive material.

Purification Methods

Separation of the m-and p-cresols requires chemical methods, such as conversion to their sulfonates [Brüchner Anal Chem 75 289 1928]. An equal volume of H2SO4 is added to m-cresol, stirred with a glass rod until solution is complete. Heat for 3hours at 103-105o. Dilute carefully with 1-1.5 volumes of water, heat to boiling point and steam distil until all unsulfonated cresol has been removed. Cool and extract the residue with ether. Evaporate the solution until the boiling point reaches 134o and steam distil off the m-cresol. Another purification method involves distillation, fractional crystallisation from the melt, then redistillation. Free from p-cresol by solution in glacial acetic acid and bromination by about half of an equivalent amount of bromine in glacial acetic acid. The acetic acid is distilled off, then fractional distillation of the residue under vacuum gives bromocresols from which 4-bromo-m-cresol is obtained by crystallisation from hexane. Addition of the bromocresol in glacial acetic acid slowly to a reaction mixture of HI and red phosphorus or (more smoothly) of HI and hypophosphorus acid, in glacial acetic acid, at reflux, removes the bromine. After an hour, the solution is distilled at atmospheric pressure until layers are formed. Then it is cooled and diluted with water. The cresol is extracted with ether, washed with water, NaHCO3 solution and again with water, dried with a little CaCl2 and distilled [Baltzly et al. J Am Chem Soc 77 2522 1955]. The 3,5-dinitrobenzoate (prepared with 3,5-dinitrobenzoyl chloride in dry pyridine, and recrystallised from EtOH or aqueous Me2CO) has m 165o. [Beilstein 6 IV 2035.]

비 호환성

Vapors may form explosive mixture with air. Incompatible with strong acids; oxidizers, alkalies, aliphatic amines; amides, chlorosulfonic acid; oleum. Decomposes on heating, producing strong acids and bases, causing fire and explosion hazard. Liquid attacks some plastics and rubber. Attacks many metals.

폐기물 처리

Wastewaters may be subjected to biological treatment. Concentrations may be further reduced by ozone treatment. High concentration wastes may be destroyed in special waste incinerators.

m-크레졸 준비 용품 및 원자재

원자재

준비 용품


m-크레졸 공급 업체

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