이 화학 물질은 눈, 호흡계 및 피부를 자극합니다. 그것은 가연성이므로 점화원으로부터 멀리 두어야합니다. - 금연. 눈과의 접촉시 즉시 다량의 물로 씻어 내고 의사의 진찰을 받으십시오. 그것을 사용할 때 피부와 눈에 닿지 않도록해야합니다.
화학적 성질
clear colorless to yellow liquid
용도
tert-Butyl Bromoacetate is a halogenated t-butyl acetate commonly used as an alkylating agent. tert-Butyl Bromoacetate is used in the synthesis of collagenase inhibitors.
제조 방법
Tert-butyl bromoacetate ester was synthesized using bromoacetic acid and isobutylene as raw materials,Amberlyst 15,a strong acidic cation exchange resin,as catalyst,and tert-butanol as modifier.
일반 설명
tert-Butyl bromoacetate serves as building blocks during the synthesis of model N-substituted oligoglycines (peptoids) containing an N-linked lactoside side-chain.
Safety
Tert-Butyl bromoacetate is a lachrymator. The reagent, reaction and its work-up should be handled in an adequately ventilated fume hood while wearing gloves, safety glasses and laboratory coat.
Purification Methods
Dissolve the ester in Et2O, wash it well with ice cold 10% aqueous K2CO3, dry it over CaCl2, filter and evaporate the Et2O, then fractionate it through a Vigreux column (p 11) in a vacuum. LACHRYMATORY. [Abramovitch et al. J Am Chem Soc 64 2274 1942, Abramovitch & Hauser J Am Chem Soc 65 986 1943, Beilstein 2 III 482.]
