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Zamifenacinfumarate C화학적 특성, 용도, 생산
용도
Zamifenacin Fumarate is a selective antagonist of mAChR M3 (M3 muscarinic receptor).
생물학적 활성
Selective M 3 muscarinic receptor antagonist (pK i values are 8.52, 7.93, 7.90 and 7.78 for M 3 , M 2 , M 1 and M 4 receptors respectively). Displays higher affinity at ileal M 3 receptors (pK i = 9.3) compared to oesophageal and tracheal M 3 receptors (pK i values are 8.8 and 8.2 respectively). In vivo, inhibits gastrointestinal motility in the absence of cardiovascular effects.
