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Esomeprazole magnesium

Esomeprazole magnesium 구조식 이미지
카스 번호:
161973-10-0
상품명:
Esomeprazole magnesium
동의어(영문):
Chebi:50309;S-Form magnesium salt;Esomeprazole magnesium;ESOMEPRAZOLE MAGNESIUM/SODIUM;ESOMEPRAZOLE MAGNESIUM SAMPLE;EsoMeprazole MagnesiuM(NexiuM);EsMeprazole Magne-siuM Trihydrate;Esomeprazole Magnesium(Random Configuration);Esomeprazole magnesium Esomeprazole magnesium(API);Magnesium 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide
CBNumber:
CB81104336
분자식:
2(C17H18N3O3S)2.Mg
포뮬러 무게:
713.12
MOL 파일:
161973-10-0.mol

Esomeprazole magnesium 속성

알파
D20 -128.2° (c = 1 in methanol)

안전

Esomeprazole magnesium C화학적 특성, 용도, 생산

용도

Antiulcerative

정의

ChEBI: A magnesium salt resulting from the formal reaction of magnesium hydroxide with 2 mol eq. of esomeprazole. An inhibitor of gastric acid secretion, it is used for the treatment of gastro-oesophageal reflux disease, dyspepsia, peptic ulcer disease, and Zolli ger-Ellison syndrome.

상표명

Nexium (AstraZeneca).

일반 설명

Esomeprazole magnesium,S-bis(5-rnethoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-l-yl) magnesiumtrihydrate (Nexium), is the S-enantiomer ofomeprazole. The benzimidazole PPIs contain a chiral sulfuratom that form an enantiomeric pair that is stable andinsoluble under standard conditions. The S-isomer ofomeprazole has slightly greater PPI activity, and its intrinsicclearance is approximately three times lower thanthat of R-omeprazole (15 vs. 43μL/min). The lowerclearance of S-omeprazole is related to slower metabolicclearance by the CYP2C19 isozyme. Although Romeprazoleis primarily transformed to the 5-hydroxymetabolite, the S-isomer is metabolized by O-demethylationand sulfoxidation, which contribute little to intrinsicclearance.

Esomeprazole magnesium 준비 용품 및 원자재

원자재

준비 용품


Esomeprazole magnesium 공급 업체

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