Esomeprazole magnesium

Esomeprazole magnesium C화학적 특성, 용도, 생산

용도

Antiulcerative

정의

ChEBI: A magnesium salt resulting from the formal reaction of magnesium hydroxide with 2 mol eq. of esomeprazole. An inhibitor of gastric acid secretion, it is used for the treatment of gastro-oesophageal reflux disease, dyspepsia, peptic ulcer disease, and Zolli ger-Ellison syndrome.

상표명

Nexium (AstraZeneca).

일반 설명

Esomeprazole magnesium,S-bis(5-rnethoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-l-yl) magnesiumtrihydrate (Nexium), is the S-enantiomer ofomeprazole. The benzimidazole PPIs contain a chiral sulfuratom that form an enantiomeric pair that is stable andinsoluble under standard conditions. The S-isomer ofomeprazole has slightly greater PPI activity, and its intrinsicclearance is approximately three times lower thanthat of R-omeprazole (15 vs. 43μL/min). The lowerclearance of S-omeprazole is related to slower metabolicclearance by the CYP2C19 isozyme. Although Romeprazoleis primarily transformed to the 5-hydroxymetabolite, the S-isomer is metabolized by O-demethylationand sulfoxidation, which contribute little to intrinsicclearance.

Esomeprazole magnesium 준비 용품 및 원자재

원자재

준비 용품

Esomeprazole magnesium 공급 업체

공급자	전화	팩스	이메일	국가	제품 수	이점
Shenzhen Sendi Biotechnology Co.Ltd.	0755-23311925 18102838259	0755-23311925	Abel@chembj.com	CHINA	3202	55
Henan DaKen Chemical CO.,LTD.	+86-371-55531817		info@dakenchem.com	CHINA	21759	58
Henan Tianfu Chemical Co.,Ltd.	0371-55170693	0371-55170693	info@tianfuchem.com	CHINA	20672	55
ATK CHEMICAL COMPANY LIMITED	+86 21 5161 9050/ 5187 7795	+86 21 5161 9052/ 5187 7796	ivan@atkchemical.com	CHINA	24192	60
Shanghai Zheyan Biotech Co., Ltd.	18017610038		zheyansh@163.com	CHINA	3623	58
career henan chemical co	+86-371-86658258		sales@coreychem.com	CHINA	27142	58
Chemwill Asia Co.,Ltd.	86-21-51086038	86-21-51861608	chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com	CHINA	23964	58
Haihang Industry Co.,Ltd	86-531-88032799	+86 531 8582 1093	export@haihangchem.com	CHINA	8260	58
Shandong chuangyingchemical Co., Ltd.	13156170209		sale@chuangyingchem.com	CHINA	4419	58
BOC Sciences	1-631-619-7922	1-631-614-7828	inquiry@bocsci.com	United States	20116	58

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