트리-o-톨릴포스핀
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트리-o-톨릴포스핀 속성
- 녹는점
- 123-125 °C(lit.)
- 끓는 점
- 412.4±44.0 °C(Predicted)
- 밀도
- 1.16[at 20℃]
- 증기압
- 0Pa at 20℃
- 인화점
- 198°C (388°F)
- 저장 조건
- Store below +30°C.
- 용해도
- 클로로포름, 에틸아세테이트에 용해됨
- 물리적 상태
- 결정성 분말
- 색상
- 하얀색
- 수용성
- 알코올에 용해됩니다. 찬물에 약간 용해됩니다. 물에 불용성.
- 감도
- air sensitive
- Hydrolytic Sensitivity
- 7: reacts slowly with moisture/water
- BRN
- 661212
- InChIKey
- COIOYMYWGDAQPM-UHFFFAOYSA-N
- LogP
- 7.2
- CAS 데이터베이스
- 6163-58-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36-37/39 | ||
WGK 독일 | 3 | ||
F 고인화성물질 | 10-23 | ||
TSCA | Yes | ||
HS 번호 | 29319090 |
트리-o-톨릴포스핀 C화학적 특성, 용도, 생산
화학적 성질
white to light yellow crystal powder.용도
Tri(o-tolyl)phosphine is used in a ruthenium-catalyzed direct amination of alcohols. It is also used in Suzuki reaction. Further, it is used in the preparation of tri-ortho-phosphinselenide by reacting with selenium as a reagent. In addition to this, it acts as a ligand in coordination chemistry.주요 응용
Tris(2-methylphenyl)phosphine (Eletriptan Impurity 13) is a phosphine catalyst. It can be used in the rhodium-catalyzed hydrogenation, Suzuki-Miyaura cross-coupling reactions and Heck reactions.제조 방법
Tri(o-tolyl)phosphine can be obtained by the reduction of tris(o-tolyl)phosphine oxide or prepared by the 2-bromotoluene Grignard reaction.Procedure: To a solution of magnesuim turnings (3.11 g, 128 mmol, 3.5 equiv) in THF (50 mL) was added a small amount of 2-bromotoluene (1 mL) and 1 iodine crystal. The reaction vessel was heated until initiation occurred, where upon a solution of the remaining 2-bromotoluene (20 g, 117 mmol, 3.2 equiv in total) in THF (100 mL) was added. The reaction was set to reflux for 2 hours (colour change to black solution), after which it was cooled to 0 oC and a solution of phosphorus trichloride (5.01 g, 36.5 mmol, 1 equiv) in THF (30 mL) was added dropwise. Upon addition completion the reaction was set to reflux for 18 hours. The reaction was allowed to cool to room temperature, whereupon NH4Cl solution was added with care. The resulting solution was extracted with ether (3 x 100 mL), dried over MgSO4, filtered and concentrated in vacuo. The resulting white solid was recrystalised from ethanol to yield Tri(o-tolyl)phosphine as a white solid. (6.8 g, 62 %)
반응 프로필
Tri(o-tolyl)phosphine is suitable for the following reaction types: Cross Couplings, Silylations, Buchwald-Hartwig Cross Coupling Reaction, Heck Reaction, Negishi Coupling, Stille Coupling, Suzuki-Miyaura Coupling.Purification Methods
It crystallises from EtOH [Boert et al. J Am Chem Soc 109 7781 1987]. [Beilstein 16 III 835.]트리-o-톨릴포스핀 준비 용품 및 원자재
원자재
에틸알코올
황산 나트륨
염화나트륨
삼염화 인
에틸렌 디브롬
테트라하이드로푸란
디에틸에테르
염화 암모늄
아이오딘
초산에틸
염산
디클로로메탄
수산화나트륨
주석산 염
o-브로모톨루엔
석유 에테르
마그네슘
준비 용품
트리-o-톨릴포스핀 공급 업체
글로벌( 498)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Tangshan Moneide Trading Co., Ltd. | +86-315-8309571 +8615633399667 |
sales@moneidechem.com | China | 568 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Shanghai UCHEM Inc. | +862156762820 +86-13564624040 |
sales@myuchem.com | China | 6710 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 |
sales@frappschem.com | China | 885 | 50 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
트리-o-톨릴포스핀 관련 검색:
트리 -m- 톨릴 포스 핀 포스핀(기체) (트리페닐포스포라닐리덴)아세트알데히드 트리 -p- 톨릴 포스 핀 트리스(2,4,6-트리메틸페닐)포스핀 트리-o-톨릴포스핀
TRIS(2-CYANOETHYL)PHOSPHINE
TRI(2-FURYL)PHOSPHINE
Eletriptan hydrobromide
Aluminum trifluoromethanesulfonate
TRIS(4,6-DIMETHYL-3-SULFANATOPHENYL)PHOSPHINE TRISODIUM SALT HYDRATE
TRIS(2,4-DIMETHYLPHENYL)PHOSPHINE
TRANS-DI(MU-ACETATO)BIS[O-(DI-O-TOLYLPHOSPHINO)BENZYL]DIPALLADIUM (II)
TRI(2,5-XYLYL)PHOSPHINE
Dibromobis(tri-o-tolylphosphine)palladium(II), Pd 12%
DICHLOROBIS(TRI-O-TOLYLPHOSPHINE)PALLADIUM(II)
Rizatriptan
TRI-P-TOLYLPHOSPHINE OXIDE