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Bupropion

Bupropion 구조식 이미지
카스 번호:
34911-55-2
상품명:
Bupropion
동의어(영문):
Bupropion;Amfebutamon;AMFEBUTAMONE;BUPROPION HCL;AMFEBUTAMONE HCL;Wellbatrin:Wellbutrin;BUPROPION/AMFEBUTAMONE;Bupropion controlled release;(a-2-(tert-butylamino)-3¢m-chloro-a-(tert-butylamino)propiophenone
CBNumber:
CB8140067
분자식:
C13H18ClNO
포뮬러 무게:
239.74
MOL 파일:
34911-55-2.mol

Bupropion 속성

녹는점
233-234°C
끓는 점
bp.005 52°
용해도
ethanol: 193 mg/mL solutions may be stored for several days at 4 °C.
물리적 상태
solid
산도 계수 (pKa)
pKa 7.0 (Uncertain)
색상
white
CAS 데이터베이스
34911-55-2(CAS DataBase Reference)

안전

위험품 표기 Xn
위험 카페고리 넘버 22
안전지침서 36
WGK 독일 3
RTECS 번호 UG8858000
위험 등급 IRRITANT

Bupropion C화학적 특성, 용도, 생산

개요

Bupropion hydrochloride, an aminoketone structurally unrelated to tricyclics or tetracyclics, is a dopamine uptake blocker with antidepressant activity. Its clinical efficacy is reportedly comparable to that of amitriptyline, yet unlike most conventional antidepressants, bupropion hydrochloride is not associated with orthostatic hypotension or other cardiovascular side-effects.

Originator

Burroughs Wellcome (United Kingdom)

용도

vasoconstrictor;non-selective agonist of all adrenergic receptors

상표명

Wellbutrin (GlaxoSmithKline); Zyban (GlaxoSmithKline).

Biological Functions

Bupropion (Wellbutrin) is a pharmacologically unique antidepressant, since it is a weak inhibitor of both dopamine and norepinephrine neuronal reuptake. However, its actual antidepressant activity is not well understood. Bupropion is generally well tolerated and does not block muscarinic, histaminergic, or adrenergic receptors. Unlike the SSRIs and venlafaxine, bupropion does not cause sexual side effects. However, it can cause CNS stimulation, including restlessness and insomnia. High doses of bupropion, given as its original formulation, were associated with a risk of seizures in 0.4% of patients. However, this risk is lower with slow-release bupropion (Wellbutrin SR). This formulation still requires dosing twice a day, and bupropion is contraindicated in patients with a history of seizures. Bupropion inhibits the cytochrome P450 2D6 isoenzyme and may elevate blood levels of drugs metabolized by this route.

일반 설명

The mechanism of action of bupropion (Wellbutrin) is consideredcomplex and reportedly involves a block of DA reuptakevia the dopamine transporter (DAT), but the overallantidepressant action is noradrenergic. A metabolite thatcontributes to the overall action and its formation can beeasily rationalized. Oxidation of one of the methyl groupson the t-butyl substituent yields hydroxybupropion, an activemetabolite. Reduction of the keto group also occurs,yielding threohydrobupropion and erythrohydrobupropion.Both of these metabolites are also active.
Hydroxybupropion is half as potent as the parent bupropion,and the hydrobupropion isomers are five times less potent.The presence of these metabolites, especially hydroxybupropionwhich is formed by cytochrome P450 2D6(CYP2D6), suggests that there will be a myriad of drug interactionswith bupropion.

Bupropion 준비 용품 및 원자재

원자재

준비 용품


Bupropion 공급 업체

글로벌( 138)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29979 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23978 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
breeduan@crovellbio.com CHINA 2313 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 0 58
Chongqing Chemdad Co., Ltd +86-13650506873
sales@chemdad.com CHINA 30864 58
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15881 69

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