2-Bromo-3-methylthiophene

2-Bromo-3-methylthiophene 구조식 이미지
카스 번호:
14282-76-9
상품명:
2-Bromo-3-methylthiophene
동의어(영문):
2B3MT;178.04;TH1-Br;2-Bromo-3-methylthio;2-bromo-3-methyltiophene;3-Methyl-2-bromothiophene;2-BROMO-3-METHYLTHIOPHENE;Thiophene,2-bromo-3-methyl-;2-Bromo-3-methylthiophene>2-Bromo-3-methylthiophene 97%
CBNumber:
CB8147031
분자식:
C5H5BrS
포뮬러 무게:
177.06
MOL 파일:
14282-76-9.mol

2-Bromo-3-methylthiophene 속성

녹는점
<25 °C
끓는 점
173-176 °C (lit.)
밀도
1.572 g/mL at 25 °C (lit.)
굴절률
n20/D 1.572(lit.)
인화점
155 °F
저장 조건
2-8°C
용해도
soluble in Chloroform, Ethyl Acetate
수용성
물에 불용성
물리적 상태
액체
Specific Gravity
1.580
색상
옅은 노랑
BRN
105719
CAS 데이터베이스
14282-76-9(CAS DataBase Reference)
NIST
Thiophene, 2-bromo-3-methyl-(14282-76-9)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,Xi,Xn
위험 카페고리 넘버 25-41-43-36/37/38-20/21/22
안전지침서 26-36/37/39-45
유엔번호(UN No.) UN 2810
WGK 독일 3
위험 참고 사항 Harmful
위험 등급 IRRITANT-HARMFUL, KEEP COLD
위험 등급 6.1
포장분류 III
HS 번호 29349990
그림문자(GHS): GHS hazard pictogramsGHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H318 눈에 심한 손상을 일으킴 심한 눈 손상 또는 자극성 물질 구분 1 위험 GHS hazard pictograms P280, P305+P351+P338, P310
예방조치문구:
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
2
2 0

2-Bromo-3-methylthiophene MSDS


2-Bromo-3-methylthiophene

2-Bromo-3-methylthiophene C화학적 특성, 용도, 생산

화학적 성질

clear colorless to light yellow liquid

용도

2-Bromo-3-methylthiophene was used in the preparation of poly(3,3′′′-dimethyl-(2,2′:5′,2′:5′,2′′′)tetrathiophene)). It was also used in the preparation of 2-bromo-3-(bromomethyl)thiophene, lachrymatory compound.

주요 응용

2-Bromo-3-methylthiophene is used as a pharmaceutical intermediate. It is used to prepare pyrazolo[3,4-d]pyrimidine derivatives as inhibitors of human enterovirus, coxsackievirus, echovirus, influenza virus, herpes simplex virus and rhinovirus. It is also used in the synthesis of oral α7 nicotinic receptor agonists.

제조 방법

2-Bromo-3-methylthiophene synthesis: To a solution of glacial AcOH (100 mL), acetic anhydride (4.0 g, 0.039 mol), and 3-methylthiophene (9.82 g, 0.100 mol) as a stirred mixture was added NBS (19.6 g, 0.11 mol) in one portion with a slight exotherm to 44 oC. After 20 min the reaction mixture was poured onto ice, neutralized with sodium bisulfite and extracted with ether. The ether layer was washed with water and concentrated to give 11.3 g (64%) of 2-bromo-3-methylthiophene as a tan colored liquid in 88% purity by GC area % analysis: 1H NMR (CDCl3) d 7.1 (d, 1H, J=5.7 Hz), 6.7 (d, 1H, J=5.9 Hz), 2.2 (s, 3H).

일반 설명

2-Bromo-3-methylthiophene is formed (approx. 90%) by bromination of 3-methyl thiophene with N-bromosuccinimide in the absence of benzoyl peroxide.

2-Bromo-3-methylthiophene 준비 용품 및 원자재

원자재

준비 용품


2-Bromo-3-methylthiophene 공급 업체

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