2-Bromo-3-methylthiophene
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2-Bromo-3-methylthiophene 속성
- 녹는점
- <25 °C
- 끓는 점
- 173-176 °C (lit.)
- 밀도
- 1.572 g/mL at 25 °C (lit.)
- 굴절률
- n
20/D 1.572(lit.)
- 인화점
- 155 °F
- 저장 조건
- 2-8°C
- 용해도
- soluble in Chloroform, Ethyl Acetate
- 수용성
- 물에 불용성
- 물리적 상태
- 액체
- Specific Gravity
- 1.580
- 색상
- 옅은 노랑
- BRN
- 105719
- CAS 데이터베이스
- 14282-76-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,Xi,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 25-41-43-36/37/38-20/21/22 | ||
안전지침서 | 26-36/37/39-45 | ||
유엔번호(UN No.) | UN 2810 | ||
WGK 독일 | 3 | ||
위험 참고 사항 | Harmful | ||
위험 등급 | IRRITANT-HARMFUL, KEEP COLD | ||
위험 등급 | 6.1 | ||
포장분류 | III | ||
HS 번호 | 29349990 |
2-Bromo-3-methylthiophene C화학적 특성, 용도, 생산
화학적 성질
clear colorless to light yellow liquid용도
2-Bromo-3-methylthiophene was used in the preparation of poly(3,3′′′-dimethyl-(2,2′:5′,2′:5′,2′′′)tetrathiophene)). It was also used in the preparation of 2-bromo-3-(bromomethyl)thiophene, lachrymatory compound.주요 응용
2-Bromo-3-methylthiophene is used as a pharmaceutical intermediate. It is used to prepare pyrazolo[3,4-d]pyrimidine derivatives as inhibitors of human enterovirus, coxsackievirus, echovirus, influenza virus, herpes simplex virus and rhinovirus. It is also used in the synthesis of oral α7 nicotinic receptor agonists.제조 방법
2-Bromo-3-methylthiophene synthesis: To a solution of glacial AcOH (100 mL), acetic anhydride (4.0 g, 0.039 mol), and 3-methylthiophene (9.82 g, 0.100 mol) as a stirred mixture was added NBS (19.6 g, 0.11 mol) in one portion with a slight exotherm to 44 oC. After 20 min the reaction mixture was poured onto ice, neutralized with sodium bisulfite and extracted with ether. The ether layer was washed with water and concentrated to give 11.3 g (64%) of 2-bromo-3-methylthiophene as a tan colored liquid in 88% purity by GC area % analysis: 1H NMR (CDCl3) d 7.1 (d, 1H, J=5.7 Hz), 6.7 (d, 1H, J=5.9 Hz), 2.2 (s, 3H).일반 설명
2-Bromo-3-methylthiophene is formed (approx. 90%) by bromination of 3-methyl thiophene with N-bromosuccinimide in the absence of benzoyl peroxide.2-Bromo-3-methylthiophene 준비 용품 및 원자재
원자재
준비 용품
2-Bromo-3-methylthiophene 공급 업체
글로벌( 377)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 |
contact@trustwe.com | China | 4930 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5960 | 58 |
Henan Fengda Chemical Co., Ltd | +8613613820652 |
info@fdachem.com | China | 4685 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 14770 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9359 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
AB PharmaTech,LLC | 323-480-4688 |
United States | 989 | 55 |
2-Bromo-3-methylthiophene 관련 검색:
메틸(3-)티오펜 2-브로모티오펜 브로모트리메틸실란 브롬화 메틸 브롬
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2,5-Dibromo-3-octylthiophene
2,5-DIBROMO-3-METHYLTHIOPHENE
2-Bromo-3-bromomethylthiophene
3-bromo-2-methylthiophene