브리바라세탐

브리바라세탐
브리바라세탐 구조식 이미지
카스 번호:
357336-20-0
한글명:
브리바라세탐
동의어(한글):
브리바라세탐
상품명:
Brivaracetam
동의어(영문):
Briviact;1-PyrrolidineacetaMide, α-ethyl-2-oxo-4-propyl-, (αS,4R)-;UCB 34714;UCB34714;UCB-34714;(S)-2-((R)-2-oxo-4-propylpyrrolidin-1-yl)butanaMide;(2S)-2-[(4R)-2-oxo-4-propylpyrrolidin-1-yl]butanamide;(alphaS,4R)-alpha-Ethyl-2-oxo-4-propyl-1-pyrrolidineacetamide;Boisitan;Boisetan;UCB-34714;Buvacitan
CBNumber:
CB81508592
분자식:
C11H20N2O2
포뮬러 무게:
212.29
MOL 파일:
357336-20-0.mol
MSDS 파일:
SDS

브리바라세탐 속성

녹는점
76.38°
알파
D25 -60.57° (c = 1 in methanol)
끓는 점
409.3±28.0 °C(Predicted)
밀도
1.062
저장 조건
Refrigerator
용해도
DMSO(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
15.74±0.50(Predicted)
색상
흰색에서 황백색까지
InChI
InChI=1/C11H20N2O2/c1-3-5-8-6-10(14)13(7-8)9(4-2)11(12)15/h8-9H,3-7H2,1-2H3,(H2,12,15)/t8-,9+/s3
InChIKey
MSYKRHVOOPPJKU-MASDURLHNA-N
SMILES
[C@H](N1C(C[C@@H](CCC)C1)=O)(CC)C(=O)N |&1:0,4,r|
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P312 삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P330 입을 씻어내시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
2 0

브리바라세탐 C화학적 특성, 용도, 생산

개요

Brivaracetam, a novel oral antiepileptic drug with a high affinity for synaptic vesicle protein 2A (SV2A), was approved in Europe and the US as an adjunctive therapy for the treatment of partial onset seizures with or without secondary generalization in patients aged 16 or older.42 Brivaracetam is very closely related to levetiracetam, an antiepileptic treatment whose immediate release formulation has been available in the United States as a generic drug since 2008, but whose extended release formulation is under patent protection until 2028. The two drugs, which were both developed by UCB Pharma, are structurally similar with brivaracetam having an n-propyl group at the C-4 position of the pyrrolidinone ring and levetiracetam having a hydrogen at this same position. A systematic investigation of the various substitutions of levetiracetam resulted in the identification of more potent and selective SV2A ligands and ultimately culminated in the discovery of brivaracetam, which has greater affinity for SV2A, improved selectivity, more rapid brain penetration, and faster onset of action against seizures than levetiracetam.

용도

Treatment ofTreatment of epilepsy, neuropathic pain and essential tremor.

정의

ChEBI: A non-proteinogenic amino acid derivative that is butanamide in which the pro-S hydrogen at position 2 is replaced by a (4R)-2-oxo-4-propylpyrrolidin-1-yl. Used for treatment of partial onset seizures related to epilepsy.

부작용

Common side effects of brivaracetam include: constipation, nausea, vomiting, extreme tiredness or low energy. Serious side effects that may be caused include: swelling of the face, throat, tongue, lips, and eyes; difficulty swallowing or breathing; hoarseness, hallucinations (seeing things or hearing sounds that are not there), and delusions (strange thoughts or beliefs that have no basis in reality). An overdose may cause: drowsiness, extreme tiredness, dizziness, difficulty maintaining balance, blurred or double vision, slowed heartbeat, nausea, and feeling anxious.

브리바라세탐 준비 용품 및 원자재

원자재

준비 용품


브리바라세탐 공급 업체

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