solid or colorless solution with characteristic alcohol odor.
제조 방법
Preparation of Clindamycin Phosphate: a solution of 808 mg of the phosphorylated ester in 6 ml of pyridine and 16 ml of acetic acid is stirred at ambient temperature while s5 mg of zinc is rapidly added. The mixture is filtered after one hour and evapo rated to a residue which is heated with stirring at 50°C. for 2 hours with a solvent mixture of 2 ml of acetic acid, and 4 ml of 0.5N sulfuric acid. The mixture is cooled and filtered followed by evaporation of the filtrate in vacuo to a residue, which is chromatographed on a suitable ion-exchange resin, in the acid form, and eluted with 2% ammonium hydroxide. The desired product is obtained as ammonium salt by evaporation of the product fractions. (dec. 212°C)
일반 설명
Clindamycin phosphate (Cleocin Phosphate) is the 2-phosphateester of clindamycin. It exists as a zwitterionic structurethat is very soluble in water. It is intended for parenteral(intravenous or intramuscular) administration for the treatmentof serious infections and instances when oral administrationis not feasible. Solutions of clindamycin phosphateare stable at room temperature for 16 days and for up to 32days when refrigerated.
색상 색인 번호
This lincosanide antibiotic is used in topical form for acne,
or systemically has been responsible for exanthematous
rashes and acute generalized exanthematous pustulosis.
Pharmacology
Clindamycin phosphate is available in 1% concentration in a hydroalcoholic
vehicle (30 or 60 mL) as a gel or lotion. Although the drug has
not been detected in the blood after topical use, its detection in the urine
suggests that 4% to 5% of topically applied clindamycin is absorbed.
