피콜린산
|
|
피콜린산 속성
- 녹는점
- 139-142 °C (lit.)
- 끓는 점
- 229.19°C (rough estimate)
- 밀도
- 1.3147 (rough estimate)
- 증기압
- 0.028Pa at 25℃
- 굴절률
- 1.5423 (estimate)
- 인화점
- 139°(232°F)
- 저장 조건
- Store below +30°C.
- 용해도
- H2O: 50 mg/mL, 투명
- 산도 계수 (pKa)
- 1.07(at 25℃)
- 물리적 상태
- 결정성 분말
- 색상
- 흰색에서 거의 흰색
- 수소이온지수(pH)
- 3.1 (50g/l, H2O, 20℃)
- 수용성
- 887g/L(20℃)
- Merck
- 14,7403
- BRN
- 109595
- InChIKey
- SIOXPEMLGUPBBT-UHFFFAOYSA-N
- LogP
- 0.72
- CAS 데이터베이스
- 98-98-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36-36/37/38 | ||
안전지침서 | 26-36-33-24/25 | ||
WGK 독일 | 3 | ||
RTECS 번호 | TJ7344000 | ||
TSCA | Yes | ||
HS 번호 | 29333999 | ||
기존화학 물질 | KE-29936 |
피콜린산 C화학적 특성, 용도, 생산
화학적 성질
Off-white to tan powder. easily soluble in glacial acetic acid, almost insoluble in ether, chloroform and carbon disulfide.용도
2-Picolinic acid is used as a chelate for alkaline earth metals. It is also used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.정의
ChEBI: Picolinic acid is a pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan. It has a role as a MALDI matrix material and a human metabolite. It is a conjugate acid of a picolinate.주요 응용
2-Picolinic acid is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Metal complexes of picolinic acid were prepared by the refluxion of metal salts and picolinic acid in ethanol taking 1:3 molar ratio for 6 hours. The solutions were concentrated and cooled, to crystallize out the complexes.The complexes were washed with ether to remove the excess ligand.
Synthesis
2-Picolinic acid synthesis: In a 500ml three-necked flask, add 100g of 2-cyanopyridine and 200g of deionized water, then start stirring, heat up to 50°C, add 128.2g of 30% sodium hydroxide to the flask, after adding, add Continue to heat up, react under reflux for 4 hours, then distill water, after 50 g of distilled water, cool the reaction solution to 20°C, add 30% hydrochloric acid, adjust the pH value of the reaction solution to 2.5, then turn on the steam to heat up the water and steam to the kettle When the temperature reaches 120°C, the reaction solution is evaporated to dryness, and the distilled water is completed. Then, 300 g of anhydrous alcohol is added dropwise to the flask to maintain the temperature of the reaction solution at 55°C. After cooling and crystallization, a solid was precipitated, filtered and dried to obtain 106.0 g of 2-picolinic acid with a yield of 89.6%.Purification Methods
Crystallise the acid from water or *benzene. The picrate has m 185-187o (from MeOH). [Beilstein 22 H 33, 22 I 502, 22 II 30, 22 III/IV 303, 22/2 V 3.]피콜린산 준비 용품 및 원자재
원자재
준비 용품
4-IODOPYRIDINE-2-CARBOXYLIC ACID
4-클로로-1-에틸-3-메틸-1H-피라졸-5-카르복실산에틸에스테르
Pyridine-2-carbonyl chloride hydrochloride
2-Aminopyridin-4-ol
2-이소시아나토피리딘
3-BROMOPYRIDINE-2-CARBOXYLIC ACID
2-Amino-4-chloropyridine
4-클로로피리딘-2-카복사미드
니코틴산
PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
2-AMINO-4-FLUOROPYRIDINE
2-(2-피리딜)벤족사졸
Methyl picolinate
피콜리닉산에틸에스테르
4-CHLORO-N,N-DIMETHYL-PYRIDINE-2-CARBOXAMIDE
Methyl 4-chloropicolinate
2-(Bromomethyl)pyridine
피리딘,2-(4,5-디하이드로-2-옥사졸릴)-(9Cl)
피콜린산 공급 업체
글로벌( 757)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +8615064153060 |
sales01@jndxj.com | China | 291 | 58 |
Shanghai UCHEM Inc. | +862156762820 +86-13564624040 |
sales@myuchem.com | China | 7192 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5895 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 2990 | 58 |
Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 |
justine@zhongda-biotech.com | China | 300 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20291 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@sdzhonghuimaterial.com | China | 983 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3002 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 |
sales@frappschem.com | China | 885 | 50 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |