세미카바자이드 하이드로클로라이드
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세미카바자이드 하이드로클로라이드 속성
- 녹는점
- 175-177 °C (dec.)(lit.)
- 끓는 점
- 394.09℃[at 101 325 Pa]
- 밀도
- 1.2908 (rough estimate)
- 증기압
- 0-0Pa at 25℃
- 굴절률
- 1.4480 (estimate)
- 저장 조건
- Store at +15°C to +25°C.
- 용해도
- H2O: 0.1 g/mL at 20 °C, 투명, 무색
- 물리적 상태
- 결정질 분말 및/또는 덩어리
- 색상
- 하얀색
- 수소이온지수(pH)
- 1.5 (100g/l, H2O, 20℃)
- 수용성
- 100g/L(15℃)
- Merck
- 14,8444
- BRN
- 3593642
- 안정성
- 안정적인. 강한 산화제, 강한 염기와 호환되지 않습니다.
- InChIKey
- XHQYBDSXTDXSHY-UHFFFAOYSA-N
- LogP
- -4.99--1.9 at 20℃
- CAS 데이터베이스
- 563-41-7(CAS DataBase Reference)
- IARC
- 3 (Vol. 12, Sup 7) 1987
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,T | ||
---|---|---|---|
위험 카페고리 넘버 | 22-40-36/38-25-45-23/24/25 | ||
안전지침서 | 24/25-22-45-53 | ||
유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
WGK 독일 | 3 | ||
RTECS 번호 | VT3500000 | ||
TSCA | Yes | ||
HS 번호 | 2928 00 90 | ||
위험 등급 | 6.1 | ||
포장분류 | III | ||
유해 물질 데이터 | 563-41-7(Hazardous Substances Data) | ||
독성 | LD50 orally in Rabbit: 123 mg/kg | ||
기존화학 물질 | KE-19983 |
세미카바자이드 하이드로클로라이드 C화학적 특성, 용도, 생산
화학적 성질
Semicarbazide hydrochloride is a white crystalline solid.용도
Semicarbazide hydrochloride is used as urease substrate and MAO inhibitor. Derivatizing agent for carbonyl compounds as their semicarbazones which produces crystalline compounds with characteristic melting points. Also used in heterocyclic synthesis. Semicarbazone formation has been used to separate carbonyl compounds from mixtures by adsorption onto silica gel from a hydrocarbon solution. Regeneration is by hydrolysis with oxalic acid.위험도
Toxic by ingestion. Questionable carcino- gen.건강위험
Semicarbazide hydrochloride is a chemical reagent, and an indicator for its metabolic parent nitrofurazone, a veterinary drug that has been banned for use in livestock production in the European Union and the U.S. amongst other jurisdictions.After Semicarbazide hydrochloride ingestion, experimental animals have developed tremors, ataxia, equilibrium difficulties, and convulsions. Its proposed mechanism of action is by binding to cytosine residues in RNA, to deoxycytosine residues in DNA and to cytosine and deoxycytosine nucleosides.
Semicarbazide hydrochloride has an oral LD50 of 225mg/kg in mice and 123 mg/kg in the rat. Some studies suggest that Semicarbazide hydrochloride is a mutagen, an animal carcinogen and a teratogen.
Due to the lack of data in humans and overall limited evidence of carcinogenicity in animals, semicarbazide hydrochloride was classified as an IARC Group 3 agent: not classifiable as to its carcinogenicity to humans. Due to its equivocal carcinogenic and mutagenic properties, when handling Semicarbazide hydrochloride and animals treated with Semicarbazide hydrochloride, it is imperative to take caution and adhere to the following guidelines to minimize exposure and the effects of exposure during normal and emergency situations.
Safety Profile
Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic and teratogenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl잠재적 노출
This material is used as a reagent for ketones and aldehydes with which it affords crystalline compounds having characteristic freezing/melting points. Also used in isolation of hormones and certain fractions from essential oils.운송 방법
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.Purification Methods
Crystallise the salt from aqueous 75% EtOH and dry it under vacuum over CaSO4. Alternatively crystallise it from a mixture of 3.6 mole % MeOH and 6.4 mole % of water. [Kovach et al. J Am Chem Soc 107 7360 1985.] IR: 700, 3500 cm-1 [Ingersoll et al. Org Synth Coll Vol I 485 1941, Davison & Christie J Chem Soc 3389 1955, Thiele & Stange Chem Ber 27 33 1894, pK: Bartlett J Am Chem Soc 54 2853 1923]. The free base crystallises as prisms from absolute EtOH, m 96o. [Curtius & Heidenreich Chem Ber 27 55 1894, Beilstein 3 IV 177.] TOXIC ORALLY, possible CARCINOGEN and TERATOGEN.비 호환성
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. May ignite combustible materials (wood, oil, paper).세미카바자이드 하이드로클로라이드 준비 용품 및 원자재
원자재
준비 용품
4,5-Dichloro-3(2H)-pyridazinone
3-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
6-AZATHYMINE
ETHYL 4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXYLATE
3-Amino-5-phenylpyrazole
Semicarbazide
4-CHLORO-2-(TETRAHYDRO-2H-PYRAN-2-YL)-5-HYDROXYPYRIDAZIN-3(2H)-ONE
5-CHLORO-4-(CHLOROMETHYL)-1,2,3-THIADIAZOLE, 97%, 97
Carbazochrome
3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
5-Chloromethyl-2H-1,2,4-triazolin-3-one
ethyl 5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate
naftazone
1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one
5-[2-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-amine
Aminoacetonesemicarbazonehydrochloride
5-(2-BROMOPHENYL)-1,3,4-OXADIAZOL-2-AMINE
세미카바자이드 하이드로클로라이드 공급 업체
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Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
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Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
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Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
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세미카바자이드 하이드로클로라이드 관련 검색:
알라닌 아미노트랜스페라제 염산아미노구아니딘 아미노아세토나이트릴 수화염화물 D-글루코사민 히드라진 아세트아미노펜 로무스팅 트라조돈 카르무스틴 나이트로푸라존 세미카바자이드 하이드로클로라이드
Semicarbazide
Topotecan hydrochloride
4-PHENYLSEMICARBAZIDE HYDROCHLORIDE
CARBOXAMIDE
4-(2-CHLOROPHENYL)SEMICARBAZIDE
4-(2-CHLOROPHENYL)SEMICARBAZIDE HYDROCHLORIDE
4-(4-METHYLPHENYLSULFONYL)SEMICARBAZIDE HYDROCHLORIDE