EST
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EST 속성
- 녹는점
- 126.2°C
- 끓는 점
- 477.88°C (rough estimate)
- 밀도
- 1.0657 (rough estimate)
- 굴절률
- 1.5800 (estimate)
- 저장 조건
- -20°C
- 용해도
- DMSO, DMF 또는 에탄올에 용해됨
- 산도 계수 (pKa)
- 13.32±0.40(Predicted)
- 물리적 상태
- 흰색 고체
- 색상
- 에탄올에서 얻은 바늘 결정체
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36-24/25 | ||
유엔번호(UN No.) | 3077 | ||
WGK 독일 | 2 | ||
RTECS 번호 | RR0404300 | ||
HS 번호 | 29242990 | ||
독성 | cyt-ham:lng 200 mg/L IYKEDH 17,815,86 |
EST C화학적 특성, 용도, 생산
개요
E-64d is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases and has diverse biological activities. It is a synthetic analog of E-64 and prodrug form of E-64c that inhibits calpain and the cysteine proteases cathepsins F, -K, -B, -H, and -L. E-64d (20-200 μM) induces cell cycle arrest at the G2/M phase in A431 human epidermoid carcinoma cells. It inhibits protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells with an IC50 value of 0.5 μM. E-46d also inhibits entry of vesicular stomatitis virus (VSV) particles pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) or SARS-CoV-2 spike glycoprotein into Vero cells, an effect that is reduced by expression of the serine protease TMPRSS2.용도
E-64d is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. E-64d has been used in combination with Prepstatin A to in terfere with autolysosomal digestion. E-64d displays neurovascular and neuronal protective effects after focal cerebral ischemia in rats.정의
ChEBI: An L-leucine derivative that is the amide obtained by formal condensation of the carboxy group of (2S,3S)-3-(ethoxycarbonyl)oxirane-2-carboxylic acid with the amino group of N-(3-methylb tyl)-L-leucinamide.Safety Profile
Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.EST 준비 용품 및 원자재
원자재
준비 용품
EST 공급 업체
글로벌( 170)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Alpha Biopharmaceuticals Co., Ltd | +86-411-39042497 +8613921981412 |
sales@alphabiopharm.com | China | 886 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 |
sales@shengdapharm.com | CHINA | 310 | 58 |
Nextpeptide Inc | +86-0571-81612335 +8613336028439 |
sales@nextpeptide.com | China | 19915 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 |
sales@tnjchem.com | China | 25363 | 58 |
Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 |
sales@dogechemical.com | China | 4128 | 58 |
EST 관련 검색:
(S)-(+)-글리시딜 메틸 에테르
EST
(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID
2-Hydroxy-4-amino butanoic acid
GLYCIDAMIDE
NALPHA-9-Fluorenylmethoxycarbonyl-S-trityl-L-cysteine pentafluorophenyl est
2,2'-[[4-[(3,5-dinitro-2-thienyl)azo]phenyl]imino]bis-ethano diacetate (est
(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC*ACID METHYL EST
Isothiocyanic acid isobutyl est
n-[3-(acetylamino)phenyl]-n-(3-methoxy-3-oxopropyl)-beta-alanin methyl est
1,2-CYCLOHEXANEDICARBOXYLICACID,BIS(2,3-EPOXYPROPYL)EST.
1,2,3,4,4a,4b,5, 6,7,9,10,10a-dodecahydro-1,4a-dimethyl-7- (1-methylethyl)-, 1,2,3-propanetriyl est1-Phenanthrenecarboxylic acid
8-FLUORO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL EST
ETHYL (2S)-2,3-EPOXYPROPANOATE
2(2-HYDROXYETHOXY)ACETAMIDE
ETHYL 2,3-EPOXYPROPANOATE
(2-AMINO-ETHOXY)-ACETIC ACID
Loxistatin acid