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Denosumab (usan)

Denosumab (usan) 구조식 이미지
카스 번호:
615258-40-7
상품명:
Denosumab (usan)
동의어(영문):
D03684;AMG 162;Denosumab;Denosumab (usan);IMMunoglobulin G2, anti-(huMan osteoclast differentiation factor) (huMan Monoclonal AMG162 heavy chain), disulfide with huMan Monoclonal AMG162 light chain, diMer
CBNumber:
CB82493606
분자식:
C6404H9912N1724O2004S50
포뮬러 무게:
0
MOL 파일:
Mol file

Denosumab (usan) 속성

안전

Denosumab (usan) C화학적 특성, 용도, 생산

개요

Denosumab, which was approved in the United States in 2010, is a fully human sequence IgG2 monoclonal antibody that inhibits bone resorption by blocking the activity of receptor activator of nuclear factor-κB ligand (RANKL). RANKL is a TNF family protein that is expressed in both secreted and cell surface forms by a variety of bone marrow cell types andmediates bone resorption through its receptor (RANK),which is found on osteoclasts and osteoclast precursors . Denosumab was discovered using XenomouseTM transgenic mice comprising human immunoglobulin genes. The antibody is approved for treatment of postmenopausal women with osteoporosis at high risk for fracture, and for the prevention of skeletal-related events in patients with bone metastases from solid tumors. Denosumab competes directly with bisphosphonates such as alendronic acid in postmenopausal osteoporosis and with zoledronic acid in both of these indications. It has been shown to have comparable efficacy and safety to bisphosphonates with some tolerability and patient acceptability advantages.

Originator

Amgen (United States)

용도

Prevention and treatment of all forms of osteoporosis or bone loss.

상표명

Prolia;Xgeva

Denosumab (usan) 준비 용품 및 원자재

원자재

준비 용품


Denosumab (usan) 공급 업체

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