(1S-cis)-Milnacipran Hydrochloride
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(1S-cis)-Milnacipran Hydrochloride 속성
- 저장 조건
- Store at -20°C
- 용해도
- DMSO:57.0(Max Conc. mg/mL);201.55(Max Conc. mM)
- 물리적 상태
- 결정성 고체
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
(1S-cis)-Milnacipran Hydrochloride C화학적 특성, 용도, 생산
개요
Levomilnacipran (Fetzima®) is a dual serotonin–norepinephrine reuptake inhibitor (SNRI) approved by the FDA in 2013 for the treatment of major depressive disorders (MDD). Levomilnacipran is the most active enantiomer of the racemate Milnacipran, which is currently used to treat pain associated with fibromyalgia. The drug was developed by Forest Laboratories and the Pierre Fabre group.용도
The S-enatiomer of Milnacipran (M344600).Synthesis
Reaction of phenylacetonitrile (100) and commercially available (R)-epichlorohydrin (101) with NaNH2 led to chloride displacement and intramolecular cyclopropanation, yielding lactone 102 after a one-pot nitrile hydrolysis and acid-promoted lactonization (75% yield over 3 steps). Lactone ring-opening with Et2NH¨CAlCl3 complex provided amido-alcohol 103, which was converted to its phthalimido derivative 104 by sequential treatment with thionyl chloride and potassium phthalimide in 80% over three steps. Finally, levomilnacipran hydrochloride (XIII) was obtained in >95% optical purity after phthalimide cleavage, HCl salt formation, and crystallization from HCl/i-PrOH/i-PrAc. This sequence represents a highly efficient route to levomilnacipran, requiring no isolation of intermediates, resulting in >40% overall yield, and allowing use of the same solvent solution (toluene) for all steps.
(1S-cis)-Milnacipran Hydrochloride 준비 용품 및 원자재
원자재
준비 용품
(1S-cis)-Milnacipran Hydrochloride 공급 업체
글로벌( 129)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 |
sales@fine-chemtech.com | CHINA | 885 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| Jurong Coupling Biotechnology Co., Ltd. | 13656108824 |
coupling278191416@hotmail.com | CHINA | 184 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 |
info@afinechem.com | CHINA | 15377 | 58 |
| Guangzhou TongYi biochemistry technology Co.,LTD | +8613073028829 |
mack@tongyon.com | China | 2996 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
(1S-cis)-Milnacipran Hydrochloride 관련 검색:
LEVOGLUCOSENONE
Methyl D-(-)-4-hydroxy-phenylglycinate
(1S,5R)-1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one
Pyridine hydrochloride
Aniline hydrochloride
Trimethylamine hydrochloride
Methylamine hydrochloride
Betaine hydrochloride
Dimethylamine hydrochloride
Cyclopropanecarboxamide,N,N-diethyl-2-(hydroxymethyl)-1-phenyl-,(1S,2R)-
(1S,2R)-2-(chloromethyl)-N,N-diethyl-1-
phenylcyclopropanecarboxamide
(S)-Amlodipine
(1S,2R)-2-((1,3-dioxoisoindolin-2-yl)Methyl)-N,N-diethyl-1-phenylcyclopropanecarboxaMide