세리티닙
|
|
세리티닙 속성
- 녹는점
- 173-175°C
- 끓는 점
- 720.7±70.0 °C(Predicted)
- 밀도
- 1.251±0.06 g/cm3(Predicted)
- 저장 조건
- -20°C Freezer
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- 10.16±0.10(Predicted)
- 물리적 상태
- 회백색 고체.
- 색상
- 흰색에서 황백색까지
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
세리티닙 C화학적 특성, 용도, 생산
개요
Ceritinib (previously LDK378l, brand name Zykadia; Novartis Pharmaceuticals) is an oral small molecule tyrosine kinase inhibitor of ALK [87]. Preclinical studies suggested that it would inhibit ROS1 as well [88, 89].용도
5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine, is a Anaplastic lymphoma kinase (ALK) inhibitor.Indications
Ceritinib (Zykadia(R), Novartis), approved in 2014, was developed as a second-generation ALK inhibitor for patients with NSCLC who have developed crizotinib resistance. Ceritinib addresses two of the most common ALK mutants that lead to crizotinib resistance, L1196M andG1269A, but is ineffective for G1202R and F1174C variants of ALK.정의
ChEBI: A member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(piperidin-4-yl)-5-methylphenyl and 2-(isopropylsulfonyl)phenyl substituents. Used for the treatment of ALK-positive metastatic non-small cell lung cancer.일반 설명
Class: receptor tyrosine kinase; Treatment: NSCLC; Elimination half-life = 41 h; Protein binding = 97%상품명
Zykadia?세리티닙 준비 용품 및 원자재
원자재
준비 용품
세리티닙 공급 업체
글로벌( 410)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
XuZhou Magic Biotechnology Co., Ltd. | +undefined13921770081 |
SVP01@magicbiotech.cn | China | 92 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1143 | 58 |
Apeloa production Co.,Limited | +8619933239880 |
admin@apcl.com.cn | China | 853 | 58 |
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 |
sales@sjar-tech.com | China | 260 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Nanjing Gold Pharmaceutical Technology Co. Ltd. | 025-84209270 15906146951 |
CHINA | 115 | 55 | |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21666 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9295 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
세리티닙 관련 검색:
Afatinib (BIBW 2992)
Vandetanib
tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate
4-(5-isopropoxy-2-Methyl-4-nitrophenyl)pyridine
1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene
LDK-378 dihydrochloride
4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-
1-broMo-5-fluoro-2-Methyl-4-nitrobenzene
1-AMINO-2-(ISOPROPYLSULPHONYL)BENZENE
2,4,5-Trichloropyrimidine
1-BroMo-5-isopropoxy-2-Methyl-4-nitrobenzene
5-Methyl-2-(1-Methylethoxy)-4-
(4-piperidinyl)- BenzenaMine hydrochloride (1:2)
Alectinib
Dabrafenib
Trametinib
Erlotinib hydrochloride
Ibrutinib
Crizotinib