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Defactinib

Defactinib 구조식 이미지
카스 번호:
1073154-85-4
상품명:
Defactinib
동의어(영문):
VS6063;VS-6063;VS 6063;CS-1796;Defactinib;Defactinib (VS-6063;VS-6063; PF-04554878;PF-04554878 Defactinib;Defactinib(PF-04554878);N-METHYL-4-(4-((3-(N-METHYLMETHYL SULFON
CBNumber:
CB82716190
분자식:
C20H21F3N8O3S
포뮬러 무게:
510.49
MOL 파일:
1073154-85-4.mol

Defactinib 속성

밀도
1.495±0.06 g/cm3(Predicted)
산도 계수 (pKa)
15.16±0.46(Predicted)

안전

Defactinib C화학적 특성, 용도, 생산

개요

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays a vital role in many oncogenic pathways. Defactinib is a dose-dependent inhibitor of FAK, with maximal inhibition of FAK autophosphorylation in cells achieved at 10 μM. It is less effective against the related kinase PYK2. Defactinib restores the chemosensitivity of taxane-resistant cells to paclitaxel (Item No. 10461), although it is not cytotoxic alone. Defactinib decreases YB-1 phosphorylation and nuclear accumulation in an Akt-dependent manner. It is orally bioavailable, inhibiting FAK and augmenting paclitaxel action in suppressing the growth and number of ovarian cancer cell tumors in mice.

용도

Defactinib is a selective and orally active FAK inhibitor phase 2. Used in treating cancer patients as it decreases proliferation and increases apoptosis.

Defactinib 준비 용품 및 원자재

원자재

준비 용품


Defactinib 공급 업체

글로벌( 73)공급 업체
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ATK CHEMICAL COMPANY LIMITED
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BOC Sciences
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Amadis Chemical Company Limited
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Chengdu Henghui Pharmaceutical Co., Ltd.
86-028-89481236 13540674322 15828370308
86-028-89481236 service@2hpharm.com China 96 58
Chengdu Henghui Pharm Tec Co. Ltd. 13540674322 15828370308
028-89481236 CHINA 121 55

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