EC 3.4.19.9;Glucarpidase;CARBOXYPEPTIDASE G;γ-glutamyl hydrolase;GAMMA-GLUTAMYL HYDROLASE;Hydrolase, gamma-glutamyl;CARBOXYPEPTIDASE G FROM PSEUDOMONAS SP.;Native Pseudomonas sp. Carboxypeptidase G;carboxypeptidase G from pseudomonas sp. purificat;Carboxypeptidase G from Pseudomonas sp. lyophilized powder, >=3 units/mg protein
눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
CARBOXYPEPTIDASE G C화학적 특성, 용도, 생산
용도
Carboxypeptidase G from Pseudomonas sp., or γ-Glutamyl hydrolase, has been used in a study to assess the role of the putidaredoxin COOH-terminus in P-450cam (cytochrome m) hydroxylations. Carboxypeptidase G from Pseudomonas sp. has also been used in a study to investigate the effects of nitric oxide on pemetrexed cytotoxicity via NO?cGMP signaling in lung adenocarcinoma cells.
Biochem/physiol Actions
Carboxypeptidase G is a lysosomal, thiol-dependent protease, which progressively cleaves γ-glutamyl pteroyl poly-γ-glutamate yielding pteroyl-α-glutamate (folic acid) and free glutamate. It is considered highly specific for the γ-glutamyl bond, but not for the C-terminal amino acid of the leaving group. Molecular mass of this homodimer is approximately 90 kDa. The enzyme is activated by Zn2+ ions.
