사이클로덱스트린
|
|
사이클로덱스트린 속성
- 녹는점
- 290-300 °C (dec.) (lit.)
- 알파
- [α]D25 +159~+165° (c=1, H2O) (After Drying)
- 끓는 점
- 844.96°C (rough estimate)
- 밀도
- 1.2296 (rough estimate)
- 굴절률
- 1.7500 (estimate)
- 저장 조건
- room temp
- 용해도
- 1M NaOH: 50mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 11.73±0.70(Predicted)
- 색상
- 하얀색
- 수소이온지수(pH)
- 5.0-8.0 (1% in solution, Ph Eur)
- 냄새
- 100.00%에서. 냄새 없는
- ?? ??
- 냄새 없는
- optical activity
- [α]20/D +162±3°, c = 1.5% in H2O
- 수용성
- 물과 수산화암모늄에 용해됩니다.
- Merck
- 14,2718
- BRN
- 78623
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- LogP
- -9.06
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-20 | ||
안전지침서 | 26-36-24/25 | ||
WGK 독일 | 2 | ||
RTECS 번호 | GU2293000 | ||
TSCA | Yes | ||
HS 번호 | 29400000 | ||
기존화학 물질 | KE-09138 |
사이클로덱스트린 C화학적 특성, 용도, 생산
화학적 성질
white powder출처
A derivative of naturally occurring starch.용도
β-Cyclodextrin is a cyclic oligosaccharide produced from starch via enzymatic conversion. β-Cyclodextrin is commonly used to produce HPLC columns allowing chiral enantiomers separation.제조 방법
Usually produced commercially from Bacillus macerans or B. circulans fermentation of starch or starch hydrolysate.생산 방법
Cyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected.Essential oil composition
In addition to carvone, the oil contains d-limonene, carveol, diacetyl furfural, methyl alcohol, acetic aldehyde and other substances. Caraway oil consists of 3.5 to 7% volatile and fatty oils; resin, sugar, tannin, mucilage.일반 설명
Beta-Cyclodextrin is the most abundant and cheap cyclic oligosaccharide that forms inclusion complexes with several drug molecules. Its main application is in tablet and capsule formulations.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Safety
Cyclodextrins are starch derivatives and are mainly used in oral and parenteral pharmaceutical formulations. They are also used in topical and ophthalmic formulations.Cyclodextrins are also used in cosmetics and food products, and are generally regarded as essentially nontoxic and nonirritant materials. However, when administered parenterally, β-cyclodextrin is not metabolized but accumulates in the kidneys as insoluble cholesterol complexes, resulting in severe nephrotoxicity.
Cyclodextrin administered orally is metabolized by microflora in the colon, forming the metabolites maltodextrin, maltose, and glucose; these are themselves further metabolized before being finally excreted as carbon dioxide and water. Although a study published in 1957 suggested that orally administered cyclodextrins were highly toxic, more recent animal toxicity studies in rats and dogs have shown this not to be the case, and cyclodextrins are now approved for use in food products and orally administered pharmaceuticals in a number of countries.
Cyclodextrins are not irritant to the skin and eyes, or upon inhalation. There is also no evidence to suggest that cyclodextrins are mutagenic or teratogenic.
β-Cyclodextrin
LD50 (mouse, IP): 0.33 g/kg(16)
LD50 (mouse, SC): 0.41 g/kg
LD50 (rat, IP): 0.36 g/kg
LD50 (rat, IV): 1.0 g/kg
LD50 (rat, oral): 18.8 g/kg
LD50 (rat, SC): 3.7 g/kg
저장
Cyclodextrins should be stored in a tightly sealed container, in a cool, dry place.Cyclodextrins are stable in the solid state if protected from high humidity.Purification Methods
Recrystallise β-cyclodextrin from water and dry it for 12hours in a vacuum at 110o, or 24hours in a vacuum at 70o. The purity is assessed by TLC on cellulose containing a fluorescent indicator. [Taguchi, J Am Chem Soc 108 2705 1986, Tabushi et al. J Am Chem Soc 108 4514 1986, Orstam & Ross J Phys Chem 91 2739 1987.] [Beilstein 19 IV 6287, 19/12 V 801.]Regulatory Status
Included in the FDA Inactive Ingredients Database: α-cyclodextrin (injection preparations); β-cyclodextrin (oral tablets, topical gels); γ-cyclodextrin (IV injections).Included in the Canadian List of Acceptable Non-medicinal Ingredients (stabilizing agent; solubilizing agent ); and in oral and rectal pharmaceutical formulations licensed in Europe, Japan, and the USA.
사이클로덱스트린 준비 용품 및 원자재
원자재
준비 용품
사이클로덱스트린 공급 업체
글로벌( 608)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 |
sales@tnjchem.com | China | 25363 | 58 |
Henan Allgreen Chemical Co.,LTD | +86-37155567971 +86-13633837469 |
info@allgreenchem.com | China | 5986 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@yibangte.com | China | 2987 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 +86-13986145403 |
info@fortunachem.com | China | 5988 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Hebei Yime New Material Technology Co., Ltd. | +86-66697723 +86-17703311139 |
admin@china-yime.com | China | 563 | 58 |
Henan Tengmao Chemical Technology Co. LTD | +8615238638457 |
salesvip2@hntmhg.com | China | 415 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7845 | 58 |
Sigma Audley | +86-18336680971 +86-18126314766 |
nova@sh-teruiop.com | China | 525 | 58 |
사이클로덱스트린 관련 검색:
덱스트린
α-Cyclodextrine
Sugammadex Impurity 52
Sugammadex sodium
6A,6B,6C,6D,6E,6F,6G-Heptakis-O-(2-hydroxypropyl)-β-cyclodextrin
Sulbactam Impurity 6
6-bromopenicillanic acid S-sulfoxide
HEXAKIS-6-BROMO-6-DEOXY-ALPHA-CYCLODEXTRIN
Acrylic acid
Sugammadex Impurity 12 Octa-Sodium Salt
Sugammadex Impurity 69
Sulbactam Impurity 8
β-Alanine
β-Amylase
β-Nicotinamide adenine dinucleotide sodium salt
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6,6-dibromo-3,3-dimethyl-7-oxo-, 4-oxide, (2S,5R)-
MALTOHEPTAOSE
Chitosan