Deoxycholic acid
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Deoxycholic acid 속성
- 녹는점
- 171-174 °C(lit.)
- 끓는 점
- 437.26°C (rough estimate)
- 알파
- 55 º (c=1, EtOH)
- 밀도
- 0.9985 (rough estimate)
- 증기압
- 0.004Pa at 20℃
- 굴절률
- 1.4460 (estimate)
- 인화점
- 9℃
- 저장 조건
- room temp
- 용해도
- 0.24g/L(15°C)
- 산도 계수 (pKa)
- 5.15(at 20℃)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 황백색까지
- optical activity
- [α]20/D +54±1°, c = 1% in ethanol
- 수용성
- 0.24g/L(15℃)
- Merck
- 14,2899
- BRN
- 3219882
- 안정성
- 안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다.
- LogP
- 5.34 at 22℃ and pH5.7
- 표면장력
- 54mN/m at 51.3mg/L and 20℃
- CAS 데이터베이스
- 83-44-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/37/38-37-20/21/22 | ||
안전지침서 | 26-36-37/39-22 | ||
유엔번호(UN No.) | UN1230 - class 3 - PG 2 - Methanol, solution | ||
WGK 독일 | 3 | ||
RTECS 번호 | FZ2100000 | ||
TSCA | Yes | ||
HS 번호 | 29181990 | ||
유해 물질 데이터 | 83-44-3(Hazardous Substances Data) | ||
독성 | LD50 oral in rat: 1gm/kg |
Deoxycholic acid C화학적 특성, 용도, 생산
개요
Deoxycholic acid sodium salt, which is a secondary bile acid and the metabolite of intestinal bacteria, provides a nonsurgical treatment to significantly reduce submental fat in adults via injection directly into moderate-to-severe fatty tissue below the neck. When injected into fatty tissue, deoxycholic acid helps destroy fat cells. Although deoxycholic acid has many applications beyond human health, the application as a dyslipidemia drug was licensed to Kythera from Los Angeles Biomedical Institute at Harbor-UCLA Medical Center in 2007. Allergan acquired Kythera recently in 2015.화학적 성질
white powder용도
Deoxycholic acid has been used in a modified procedure to recover 40-80% of a protein from a 1 μg/mL solution. It forms complexes with fatty acid. Used as an emulsifying agent in food, a precursor in the synthesis of cortisone, and a gallbladder stimulant. It has been used to study assess how physiological concentrations of ursodeoxycholic acid (UDCA) vs. deoxycholic acid (DCA) affect barrier function in mouse intestinal tissue. Deoxycholic acid has been used in a study to assess a pH-Responsive Mechanism of a Deoxycholic Acid and Folate Co-Modified Chitosan Micelle under Cancerous Environment. It has also been used in a study to investigate dose-dependent anti-inflammatory effect of ursodeoxycholic acid in experimental colitis.일반 설명
This [TM="Certified Spiking Solution" is suitable for use as starting material in the preparation of linearity standards, calibrators, and controls in LC-MS/MS and GC/MS bile acid testing methods. Deoxycholic acid (DCA), also known as deoxycholate and cholanoic acid is a secondary bile acid that aids in the absorption of fats in the intestine. Mass spectrometry-based analysis of DCA is routinely performed in clinical diagnostic testing applications including neonatal testing of inborn errors of bile acid synthesis and differentiating among types of familial intrahepatic cholestasis.Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion and intravenous routes. Questionable carcinogen with experimental tumorigenic data. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.Purification Methods
Reflux the acid with CCl4 (50mL/g), filter, evaporate under vacuum at 25o, recrystallise the residue from acetone and dry it under vacuum at 155o [Trenner et al. J Am Chem Soc 76 1196 1954]. A solution of (cholic acid-free) material (100mL) in 500mL of hot EtOH is filtered, evaporate it to less than 500mL on a hot plate, and pour it into 1500mL of cold diethyl ether. The precipitate, filtered off by suction, is crystallised twice from 1-2 parts of absolute EtOH, to give an alcoholate, m 118-120o, which is dissolved in EtOH (100mL for 60g) and poured into boiling water. After boiling until free of the EtOH, the precipitate is filtered off, dried, ground and dried to constant weight in vacuo [Sobotka & Goldberg Biochem J 26 555 1932]. Deoxycholic acid is also freed from fatty acids and cholic acid by silica gel chromatography and elution with 0.5% acetic acid in ethyl acetate [Tang et al. J Am Chem Soc 107 4058 1985]. It can also be recrystallised from butanone. Its solubility in H2O at 15o is 0.24g/L, but in EtOH it is 22.07g/L. [Beilstein 10 IV 1608.]Deoxycholic acid 준비 용품 및 원자재
원자재
준비 용품
Deoxycholic acid 공급 업체
글로벌( 569)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
Hong Kong Excellence Biotechnology Co., Ltd. | +86-86-18838029171 +8618126314766 |
ada@sh-teruiop.com | China | 892 | 58 |
Henan Tengmao Chemical Technology Co. LTD | +8615238638457 |
salesvip2@hntmhg.com | China | 415 | 58 |
Sigma Audley | +86-18336680971 +86-18126314766 |
nova@sh-teruiop.com | China | 524 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@airuikechemical.com | China | 994 | 58 |
Shanghai Aosiris new Material Technology Co., LTD | +8615139564871 |
wrjmoon2000@163.com | China | 354 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 |
sales@frappschem.com | China | 885 | 50 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15371 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
Deoxycholic acid 관련 검색:
우르소데옥시콜산 스테아르산 시트르산 엽산 세노디올 나트륨 데스옥시클로산 아세트산 염소 산 하이오디옥시콜산
Hyaluronic acid
DEOXYCHOLIC ACID SODIUM SALT MONOHYDRATE,7-DEOXYCHOLIC ACID SODIUM SALT MONOHYDRATE
Allo-UDCA
(4R)-4-[(3S,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
Dehydrocholic acid
GLYCODEOXYCHOLIC-2,2,4,4-D4 ACID
12-epi-Deoxycholic acid,3-epi-Deoxycholic acid,3,12-epi-Deoxycholic acid
(+)-NEOMENTHOL
(2R,5S)-5-(5-Fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester