ChemicalBook >제품 카탈로그 >1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER 구조식 이미지

카스 번호:: 53554-29-3

상품명:: 1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER

동의어(영문):: BUTTPARK;AvafilImpurity32;BUTTPARK 21\07-73;RSYY(Apremilast)-4;Avanafil Impurity 86;1,4-Dihydro-2-(methylthio)-4-oxo-5;1,4-DHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE;1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-;4-hydroxy-2-methylthiopyrimidine-5-ethyl formate;Ethyl 4-hydroxy-2-methylthio-5-pyrimidinecarboxylate

CBNumber:: CB8337586

분자식:: C8H10N2O3S

포뮬러 무게:: 214.24

MOL 파일:: 53554-29-3.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 190

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER 속성

녹는점: 136-144°C

밀도: 1.37±0.1 g/cm3(Predicted)

저장 조건: 2-8°C

산도 계수 (pKa): 6.48±0.50(Predicted)

CAS 데이터베이스: 53554-29-3(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xi
위험 등급	IRRITANT
HS 번호	2933599590

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER C화학적 특성, 용도, 생산

용도

1,4-Dihydro-2-methylmercapto-4-oxo-5-pyrimidinecarboxylic acid ethyl ester can be used as several synthetic intermediates and pharmaceutical intermediates, mainly used in laboratory research and development process and pharmaceutical and chemical production process.

Synthesis

Methylthiourea sulfate (75.2g, 0.4mol) was added to 16% NaOH (250mL, 1.18mol) solution and stirred for 30min, then diethyl ethoxymethylenemalonate (103.4g, 0.48 mol) was dissolved in 160 mL of ethanol and slowly dropped into the reaction solution. After the dropwise addition was completed, the reaction was carried out at room temperature for 10 h.When a large amount of white solid was precipitated, carry out suction filtration, wash with water, and vacuum dry to obtain a white solid (84.7g, 99.7%); ESE-MS (m/z): 249[M+H]+, 236.9[M+Na]+ , after verification, the product is 1,4-dihydro-2-methylmercapto-4-oxo-5-pyrimidinecarboxylic acid ethyl ester.

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER 준비 용품 및 원자재

원자재

에틸알코올 무수초산 수산화칼륨 에톡시메틸렌말론산 디에틸에스테르 오소포름산에틸 나트륨 포스포러스옥시클로라이드 벤젠 2-Methyl-2-thiopseudourea sulfate 말론산 디에틸

준비 용품

5-PyriMidinecarboxylic acid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)- 1-pyrrolidinyl]- 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER 공급 업체

글로벌( 190)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Chongqing Ensky Pharmaceutical Co.,Ltd.	+86-23-86815286 +86-13983794297	sales@ensky-chemical.com	China	87	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10828	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER 관련 검색:

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER ETHYL 5-PYRIMIDINECARBOXYLATE 98 ETHYL 2-(METHYLSULFANYL)-4-[3-(TRIFLUOROMETHYL)PHENOXY]-5-PYRIMIDINECARBOXYLATE Avanafil Impurity 9 Avanafil Impurity 19 Avanafil Impurity 24 4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine Avanafil Impurity 10 Avanafil Impurity 16 Avanafil Impurity 26 1364671-52-2 5-PyriMidinecarboxylic acid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)- 1-pyrrolidinyl]- Avanafil iMpurity 5 4-((3-Chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylic acid Avanafil Impurity 23 Avanafil iMpurity 2 Avanafil Impurity 20 Avanafil Impurity 25