Glycocholic acid

Glycocholic acid 구조식 이미지
카스 번호:
475-31-0
상품명:
Glycocholic acid
동의어(영문):
GLYCITIN;cholylglycine;GLYCOCHOLIC ACID HYDRATE;N-Cholylglycine;[(3,7,12-Trihydroxy-24-oxocholan-24-yl)amino]acetic acid;GLYCOCHOLIC;N-cholyglycine;glycocholicaci;Cholylglycinate;lycocholic acid
CBNumber:
CB8378590
분자식:
C26H43NO6
포뮬러 무게:
465.63
MOL 파일:
475-31-0.mol
MSDS 파일:
SDS

Glycocholic acid 속성

녹는점
128°C
끓는 점
568.76°C (rough estimate)
밀도
1.1336 (rough estimate)
굴절률
1.6000 (estimate)
저장 조건
Refrigerator
용해도
메탄올: 0.1 g/mL, 투명, 무색
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
4.4(at 25℃)
색상
흰색에서 황백색까지
수용성
329.9mg/L(20℃)
Merck
13,4507
안정성
흡습성
InChIKey
RFDAIACWWDREDC-NSPZZGDONA-N
LogP
1.650
CAS 데이터베이스
475-31-0(CAS DataBase Reference)
NIST
Glycocholic acid(475-31-0)
안전
  • 위험 및 안전 성명
위험품 표기 N
위험 카페고리 넘버 51/53
안전지침서 61
유엔번호(UN No.) UN 3077 9/PG 3
WGK 독일 3
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
예방조치문구:
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
NFPA 704
3
2 0

Glycocholic acid C화학적 특성, 용도, 생산

개요

Glycocholic acid is a glycine-conjugated form of the primary bile acid cholic acid and has roles in the emulsification of fats. It reduces expression of the gene encoding the farnesoid X receptor (FXR) and increases expression of the genes encoding the bile acid receptors TGR5 and S1PR2 in SNU-245 cells when used at a concentration of 1.6 μmol/ml. Glycocholic acid (250 μM) increases the intracellular accumulation and cytotoxicity of epirubicin in Caco-2 cells, as well as decreases expression of the genes encoding multidrug resistance protein 1 (MDR1), MDR-associated protein 1 (MRP1), and MRP2 when used alone or in combination with epirubicin. It increases absorption of epirubicin into everted sacs of rat ileum and jejunum when used at a concentration of 250 μM. The bile acid composition ratio of glycocholic acid is elevated in bile of patients with cholangiocarcinoma compared with patients with pancreatic cancer or benign biliary diseases. Serum levels of glycocholic acid are elevated in patients with hepatocellular carcinoma compared with healthy individuals.

화학적 성질

Off-White Solid

용도

Labelled Glycocholic Acid. The product of conjugation of cholic acid with glycine; chief ingredient of the bile of herbivorous animals. In the weakly alkaline bile fluid glycocholic acid exists as the sodium salt.

정의

ChEBI: A bile acid glycine conjugate having cholic acid as the bile acid component.

Purification Methods

Glycocholic acid crystallises from hot water as the sesquihydrate. Dry it at 110o in vacuo. An analytical sample is prepared by suspending the acid (4g) in H2O (400mL) at ~20o, heating to boiling with slow stirring, filtering hot and allowing to cool to ~20o. The acid is filtered off, washed with H2O, dried in air, recrystallised from 5% aqueous EtOH, washed well and dried over P2O5 in a moderate vacuum to constant weight. Recrystallisation from EtOH/EtOAc, and drying, gave the anhydrous acid. [Cortese & Bauman J Am Chem Soc 57 1393 1935, Bergstrom & Norman Acta Chem Scand 7 1126 1953, Beilstein 10 IV 2077.]

Glycocholic acid 준비 용품 및 원자재

원자재

준비 용품


Glycocholic acid 공급 업체

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Sense Chemicals (Shanghai) Co., Ltd.
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CONIER CHEM AND PHARMA LIMITED
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Antai Fine Chemical Technology Co.,Limited
18503026267
info@antaichem.com CHINA 9641 58
SIMAGCHEM CORP
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sale@simagchem.com China 17368 58

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