THYROGLOBULIN, HUMAN

THYROGLOBULIN, HUMAN 구조식 이미지
카스 번호:
9010-34-8
상품명:
THYROGLOBULIN, HUMAN
동의어(영문):
proloid;Elityran;Thyractin;TG, HUMAN;HSDB 3190;THYROGLOBULIN;thyroglobulins;thyroidglobulin;Globulins, thyro;TG, HUMAN THYROID
CBNumber:
CB8390318
분자식:
포뮬러 무게:
0
MOL 파일:
Mol file
MSDS 파일:
SDS

THYROGLOBULIN, HUMAN 속성

저장 조건
-20°C
용해도
H2O: 20 mg/mL
물리적 상태
가루
색상
흰색에서 황갈색까지

안전

안전지침서 22-24/25
WGK 독일 3
F 고인화성물질 8-10-21
HS 번호 3504009000
유해 물질 데이터 9010-34-8(Hazardous Substances Data)

THYROGLOBULIN, HUMAN C화학적 특성, 용도, 생산

개요

Thyroglobulin is of special importance, because it serves as the matrix for the synthesis of T4 and T3 and as the storage form of the hormones and iodide. Thyroglobulin, a large glycoprotein with a molecular weight of 660,000 Da, accounts for about one-third of the weight of the thyroid gland. Thyroglobulin carries an average of 6 tyrosyl residues as monoiodo-L-tyrosine, 5 residues as diiodo-L-tyrosine, 0.3 residues as T3, and 1 residue as T4. From these values, it can be estimated that a 20 g thyroid stores roughly 10 μmol (7.8 mg) of T4 and 3 μmol (2.0 mg) of T3 and that the normal human thyroid gland contains enough potential T4 to maintain a euthyroid state for 2 months without new synthesis.
The synthesis of the thyroid hormones, T3 and T4, is regulated by thyrotropin (thyroid-stimulating hormone [TSH]), which stimulates the synthesis of thyroglobulin, thyroperoxidase (TPO), and hydrogen peroxide. The formation of the thyroid hormones depends on an exogenous supply of iodide. The thyroid gland is unique in that it is the only tissue of the body able to accumulate iodine in large quantities and incorporate it into hormones. Approximately 25% of the body's supply of iodide is located in the thyroid gland. The iodine atoms play a unique role in the conformational preferences for T3 and T4 because of their large steric bulkiness. The metabolism of iodine is so closely related to thyroid function that the two must be considered together. The formation of thyroid hormones involves the following complex sequence of events: 1) active uptake of iodide by the follicular cells, 2) oxidation of iodide and formation of iodotyrosyl residues of thyroglobulin, 3) formation of iodothyronines from iodotyrosines, 4) proteolysis of thyroglobulin and release of T4 and T3 into blood, and 5) conversion of T4 to T3.

용도

Proloid (Parke-Davis).

Biological Functions

Thyroid hormones regulate the turnover of carbohydrates, lipids, and proteins. They promote glucose absorption, hepatic and renal gluconeogenesis, hepatic glycogenolysis, and glucose utilization in muscle and adipose tissue. They increase de novo cholesterol synthesis but increase low-density lipoprotein degradation and cholesterol disposal even more, leading to a net decrease in total and in low-density lipoprotein cholesterol plasma levels. Thyroid hormones are anabolic when present at normal concentrations; they then stimulate the expression of many key enzymes of metabolism.

일반 설명

Thyroglobulin, a glycoprotein, is composed of several peptidechains; it also contains 0.5% to 1% iodine and 8% to10% carbohydrate in the form of two types of polysaccharide.The formation of thyroglobulin is regulated by TSH.Thyroglobulin has no hormonal properties. It must be hydrolyzedto release the hormonal iodothyronines thyroxineand liothyronine.

Mechanism of action

The two most important actions of thyroid hormone are those related to oxygen consumption and those related to protein synthesis. Most effects of thyroid hormones can be related to the activation of genes following the binding of the hormone to high-affinity receptors of cell nuclei, but direct interactions of thyroid hormones with other cellular receptors cannot be excluded.

THYROGLOBULIN, HUMAN 준비 용품 및 원자재

원자재

준비 용품


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