토코페솔란

토코페솔란
토코페솔란 구조식 이미지
카스 번호:
9002-96-4
한글명:
토코페솔란
동의어(한글):
토코페솔란
상품명:
Tocofersolan
동의어(영문):
tpgs;VITAMIN E TPGS;Vitamin E polyethylene glycol succinate;d-alpha-tocopheryl polyethylene glycol succinate;Tocophersolan;D-α-Tocopherol polyethylene glycol succinate;tocopherosolan;D-a-Tocopherol Polyethylene Glycol Succinate;d-alpha-tocopherylpoly(ethyleneglycol)1000succinate;D-a-Tocopherol Polyethylene Glycol Succinate (Vitamin E TPGS)
CBNumber:
CB8396198
분자식:
(C2H4O)nC33H54O5
포뮬러 무게:
0
MOL 파일:
9002-96-4.mol
MSDS 파일:
SDS

토코페솔란 속성

녹는점
34-38°C
저장 조건
2-8°C
용해도
H2O: 가용성 1g/10mL, 투명하거나 희미한 혼탁함, 무색 내지 희미한 노란색
물리적 상태
고체
물리적 상태
단단한 모양
색상
흰색에서 연한 노란색 왁스
InChI
InChI=1S/C34H56O6/c1-23(2)12-9-13-24(3)14-10-15-25(4)16-11-20-34(8)21-19-29-28(7)32(26(5)27(6)33(29)40-34)39-31(37)18-17-30(36)38-22-35/h23-25,35H,9-22H2,1-8H3
InChIKey
WFWQYXBTWIHIIW-UHFFFAOYSA-N
SMILES
C(=O)(OC1C(C)=C2CCC(C)(CCCC(CCCC(CCCC(C)C)C)C)OC2=C(C)C=1C)CCC(=O)OCO
LogP
9.745 (est)
안전
  • 위험 및 안전 성명
WGK 독일 2
RTECS 번호 TR1581200
HS 번호 2936.28.0000
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
예방조치문구:
NFPA 704
1
0 0

토코페솔란 MSDS


D-alpha-Tocopheryl polyethylene glycol succinate

토코페솔란 C화학적 특성, 용도, 생산

화학적 성질

Vitamin E polyethylene glycol succinate is a synthetic product. It is available as a white to light-brown, waxy solid and is practically tasteless. Chemically, it is a mixture composed principally of monoesterified polyethylene glycol 1000, the diesterified polyethylene glycol 1000, free polyethylene glycol 1000, and free tocopherol.

생산 방법

Vitamin E polyethylene glycol succinate is prepared by esterification of the acid group of crystalline D-a-tocopheryl acid succinate by polyethylene glycol 1000.

Pharmaceutical Applications

Vitamin E polyethylene glycol succinate is an esterified vitamin E (tocopherol) derivative primarily used as a solubilizer or emulsifying agent because of its surfactant properties. Structurally, it is amphipathic and hydrophilic, unlike the tocopherols, and therefore it is a water-soluble derivative that can be used in pharmaceutical formulations such as capsules, tablets, hot-melt extrusion, microemulsions, topical products, and parenterals. One of the most important applications is its use as a vehicle for lipid-based drug delivery formulations. It can also be used as a source of vitamin E.
Vitamin E polyethylene glycol succinate has been characterized with respect to its mechanism of action and studied as a Pglycoprotein inhibitor.

Safety

Vitamin E polyethylene glycol succinate has been used at levels of 280 mg/capsule in the product Agenerase (amprenavir), which was dosed at 8 capsules (2240mg vitamin E TPGS) per day. An additional assessment of the safety of vitamin E polyethylene glycol succinate has been published, which includes a report showing no-observed-adverse-effect-level (NOAEL) in rats of 1000 mg/kg/day.

저장

Vitamin E polyethylene glycol succinate is stable at ambient room temperature for up to 4 years. It reacts with alkalis and acids. Aqueous solutions of vitamin E polyethylene glycol succinate are stable over a pH range of 4.5–7.5 and can be further stabilized with propylene glycol.

비 호환성

Vitamin E polyethylene glycol succinate is incompatible with strong acids and strong alkalis.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (ophthalmic solution or drops; oral capsules, solution, tablet; topical solution or drops). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

토코페솔란 준비 용품 및 원자재

원자재

준비 용품


토코페솔란 공급 업체

글로벌( 257)공급 업체
공급자 전화 이메일 국가 제품 수 이점
Shaanxi LonierHerb Bio Technology Co Ltd
+86-86-+86-86-029-87551862 +8617702909819
sales006@ingredients-lonier.com China 2595 58
Hebei Mojin Biotechnology Co., Ltd
+8613288715578
sales@hbmojin.com China 12452 58
Hebei Guanlang Biotechnology Co,.LTD
+8619930503252
daisy@crovellbio.com China 5966 58
Shaanxi Haibo Biotechnology Co., Ltd
+86-02963020060 +86-18629295024
hibo06@xaltbio.com China 1000 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806
sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21700 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3012 60
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282
alice@crovellbio.com China 8823 58
Shanghai Worldyang Chemical Co.,Ltd.
,+86-21-56795779; +8613651600618
sales@worldyachem.com China 879 58

토코페솔란 관련 검색:

Copyright 2019 © ChemicalBook. All rights reserved