플루드록시코르타이드

플루드록시코르타이드
플루드록시코르타이드 구조식 이미지
카스 번호:
1524-88-5
한글명:
플루드록시코르타이드
동의어(한글):
플루드록시코르타이드;플루드록시코르타이드;플루란드레놀라이드;플루란드레놀라이드
상품명:
Flurandrenolide
동의어(영문):
33379;haelan;l33379;cordan;drocort;Sermaka;Astonin;cordran;drenison;alondra-f
CBNumber:
CB8420972
분자식:
C24H33FO6
포뮬러 무게:
436.51
MOL 파일:
1524-88-5.mol

플루드록시코르타이드 속성

녹는점
247-255°
알파
D +140-150° (CHCl3)
끓는 점
578.7±50.0 °C(Predicted)
밀도
1.0796 (rough estimate)
굴절률
1.5980 (estimate)
저장 조건
-20°C Freezer, Under inert atmosphere
용해도
클로로포름(약간 용해됨), 에틸아세테이트(약간 용해됨), 메탄올(약간 용해됨)
용해도
클로로포름(약간), 에틸아세테이트(약간), 메탄올(약간)에 용해됨
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
12.87±0.10(Predicted)
색상
흰색에서 황백색까지
수용성
295mg/L(25℃)
EPA
Fluradrenolide (1524-88-5)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
WGK 독일 3
RTECS 번호 TU5024800
HS 번호 2937220000
유해 물질 데이터 1524-88-5(Hazardous Substances Data)
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
0
2 0

플루드록시코르타이드 MSDS


Flurandrenolide

플루드록시코르타이드 C화학적 특성, 용도, 생산

용도

Flurandrenolide (Cordran, Cordran SP) is a synthetic fluorinated corticosteroid.

Indications

Flurandrenolide (Cordran, Cordran SP) is a synthetic fluorinated corticosteroid.

Biological Functions

Corticosteroids influence all tissues of the body and produce numerous and varying effects in cells. These steroids regulate carbohydrate, lipid, and protein biosynthesis and metabolism (glucocorticoid effects), and they influence water and electrolyte balance (mineralocorticoid effects). Cortisol is the most potent glucocorticoid secreted by the adrenal gland, and aldosterone is the most potent endogenous mineralocorticoid. Both naturally occurring glucocorticoids and related, semisynthetic analogues can be evaluated in terms of their ability to sustain life, to stimulate an increase in blood glucose concentrations and a deposition of liver glycogen, to decrease circulating eosinophils, and to cause thymus involution in adrenalectomized animals. In addition, corticosteroids can affect immune system functions, inflammatory responses, and cell growth. The primary physiologic function of glucocorticoids is to maintain blood glucose levels and, thus, ensure glucose-dependent processes critical to life, particularly brain functions. Cortisol and related steroids accomplish this by stimulating the formation of glucose, by diminishing glucose use by peripheral tissues, and by promoting glycogen synthesis in the liver to increase carbohydrate stores for later release of glucose.

일반 설명

Flurandrenolide, 6α-fluoro-11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione, although available as a tape product,can stick to and remove damaged skin, so it should beavoided with vesicular or weeping dermatoses.

Mechanism of action

Glucocorticoid action is mediated through the glucocorticoid receptor, which is found primarily in the cytosol of the cell when not bound to glucocorticoids. The GR is stabilized in the cytosol by complexation with phosphorylated proteins, including a 90-kDa protein referred to as a heat shock protein 90. The steroid molecule binds to the GR, resulting in a conformational change of the receptor to dissociate the other proteins and initiate translocation of the steroid–receptor complex into the nucleus. The steroid–nuclear GR complex interacts with particular HRE regions of the cellular DNA, referred to as glucocorticoid-responsive elements and initiates transcription of the DNA sequence to produce mRNA. Finally, the elevated levels of mRNA lead to increased protein synthesis in the endoplasmic reticulum. These proteins then mediate glucocorticoid effects on carbohydrate, lipid, and protein metabolism. An alternative isoform of the GR has been identified. This isoform of the receptor does not bind known glucocorticoids, and its function remains to be determined.

Clinical Use

Two major uses of glucocorticoids are in the treatment of rheumatoid diseases and allergic manifestations. Their use in the treatment of severe asthma is well documented, as is the utility of glucocorticoids in sepsis and acute respiratory distress syndrome. They are effective in the treatment of rheumatoid arthritis, acute rheumatic fever, bursitis, spontaneous hypoglycemia in children, gout, rheumatoid carditis, sprue, allergy (including contact dermatitis), and other conditions. The treatment of chronic rheumatic diseases and allergic conditions with glucocorticoids is symptomatic and continuous. Symptoms return after withdrawal of the drug.

부작용

Although side effects and toxicities vary with the drug and, sometimes, with the patient, facial mooning, flushing, sweating, acne, thinning of the scalp hair, abdominal distention, and weight gain are observed with most glucocorticoids. Protein depletion (with osteoporosis and spontaneous fractures), myopathy (with weakness of muscles of the thighs, pelvis, and lower back), and aseptic necrosis of the hip and humerus are other side effects.

플루드록시코르타이드 준비 용품 및 원자재

원자재

준비 용품


플루드록시코르타이드 공급 업체

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