KN-62
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KN-62 속성
- 녹는점
- 92-94°C
- 끓는 점
- 964.7±75.0 °C(Predicted)
- 밀도
- 1.388
- 저장 조건
- -20°C
- 용해도
- 45%(w/v) 수성 2-히드록시프로필-β-시클로덱스트린: 0.93mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 4.07±0.13(Predicted)
- 색상
- 하얀색
- CAS 데이터베이스
- 127191-97-3(CAS DataBase Reference)
안전
| 안전지침서 | 24/25 | ||
|---|---|---|---|
| WGK 독일 | 3 | ||
| HS 번호 | 29339980 |
KN-62 C화학적 특성, 용도, 생산
화학적 성질
Yellow Solid용도
It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).일반 설명
A cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.생물학적 활성
Selective, cell-permeable inhibitor of CaM kinase II (IC 50 = 0.9 μ M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X 7 receptor (IC 50 = 15 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .KN-62 준비 용품 및 원자재
원자재
준비 용품
KN-62 공급 업체
글로벌( 177)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9353 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 |
sale04@alfachem.cn | China | 12377 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29627 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 |
info@finetechnology-ind.com | China | 9587 | 58 |
KN-62 관련 검색:
1-아미노에틸피페라진 5-이소퀴놀린술폰산
4-Methyl-1-piperazineethanamine
1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE
1-(3-PHENYLPROPYL)PIPERAZINE
1-Acetylpiperazine
N-[2-(4-HYDROXYPHENYL)ETHYL]-METHANESULFONAMIDE
2-(4-PHENYLPIPERAZIN-1-YL)ETHANAMINE
KN-62
N-phenethylmethanesulphonamide
1-(PROPANOYL)-PIPERAZINE
1-(4-phenylpiperazin-1-yl)propan-2-amine
1-(4-PHENYLPIPERAZIN-1-YL)ETHANONE
1-ETHYL-4-PHENYLPIPERAZINE
1-Piperazineethanamine,N,4-dimethyl-(9CI)
KN-62 **NOT FOR SALE IN JAPAN**
KN-62: HBC COMPLEX