에르고티오네인

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에르고티오네인 C화학적 특성, 용도, 생산

개요

L-(+)-Ergothioneine is a naturally-occurring amino acid derived from histidine via hercynine. Ergothioneine is a stable antioxidant that scavenges and detoxifies free radicals and oxidants, increases intracellular thiol levels, controls nuclear factor-κB activation, and inhibits inflammatory gene expression. In addition, it inhibits the peroxynitrite-dependent nitration of nitrotyrosine, blocks oxidative DNA damage and cell death, and prevents the formation of xanthine and hypoxanthine. Ergothioneine is transported by the organic cation/carnitine transporter 1, which has been linked with autoimmune diseases, including rheumatoid arthritis and Crohn’s disease.

화학적 성질

White Solid

Origin

Ergothioneine was discovered in 1909 by Charles Tanret, a French pharmacist and chemist. Tanret was examining the ergot fungus, which had recently been responsible for destroying crops, and he discovered the compound by using a purification process. The amino acid name ergothioneine originates from this fungus. Though this discovery is relatively recent, scientists speculate that ergothioneine may have originated from ancient earth. Due to its anaerobic nature (it does not require oxygen to function), it may have manifested in the earth's oxygen-free atmosphere more than three billion years ago While ergothioneine is not classified as one of the nine essential amino acids.

benefits

L-(+)-Ergothioneine is a natural antioxidant, which has various physiological functions such as scavenging free radicals, detoxification, maintaining DNA biosynthesis, normal cell growth and cellular immunity.

일반 설명

L-(+)-Ergothioneine (ERG)  is a substance that cannot be synthesized by humans and must be obtained from food. It has cytoprotective and antioxidant properties.

일반 설명

L-(+)-Ergothioneine (ET) is a sulfur-containing amino acid, which is only produced by Actinomycetales bacteria and non-yeast like fungi belonging to the division Basidiomycota and Ascomycota. It was originally isolated from Claviceps purpurea or rye ergot. It is obtained from L-histidine, which is converted into betaine form called hercynine. It is found in both animals and plants, and mammals usually obtain it from their diet, e.g. through mushrooms or oats. It is tautomeric in nature, and in neutral aqueous solution exists in thione form.

Synthesis

L-(+)-Ergothioneine is prepared by the reaction of hercynine. The steps are as follows:
15g of compound was added to 150ml of water, and 15.6g of concentrated hydrochloric acid was added, add 10.9g dibromohydantoin, stir for 20min, add D-cysteine, Continue to stir for 1 hour, add sodium thiosulfate, raise the temperature to 90-100°C, and continue the reaction for 15 hours. After the reaction, cool down and filter, adjust the pH to neutral, desalt, concentrate, crystallize with 5ml of water and 75ml of isopropanol, and dissolve the solid Filter and dry at 70-80°C to obtain 88% ergothioneine product with a yield of 81%.

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에르고티오네인 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Huzhou Haipu Chemical Co.,Ltd	+86-0572-+86-0572-2526078 +8613757061525	xatyang@acetylacetone.net	China	16	58
Shanghai EGT Synbio Group Co., Ltd.	+86-021-61453999 +8618621797362	yg@ygingredients.com	China	1	58
Chengdu Greenpure Biopharma CO.,Ltd	18283602253	jancyzheng@gcgreenpure.com	China	952	58
Maintain Biotech Co., Ltd.	+86-75589664337 +86-15112661142	cami@maintain-bio.com	China	47	58
Chemsigma International Co., Ltd.	+86-18136843612 +86-19951791336	info@chemsigma.com	China	963	58
Bonerge(Hunan) Lifescience Co., Ltd.	+86-731-82791134 +86-18801900056	hank.h@bonerge.com	China	30	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58
Biopole Pharmatech Co., Ltd.	+8615151475053	biopole@163.com	China	37	58
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	224	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12453	58

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