AA-CW236
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AA-CW236 속성
- 끓는 점
- 535.0±60.0 °C(Predicted)
- 밀도
- 1.43±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- -0.37±0.10(Predicted)
- 색상
- 흰색에서 베이지색
안전
AA-CW236 C화학적 특성, 용도, 생산
용도
AA-CW236 has been used as an inhibitor of m6G DNA methyltransferase in mouse embryo fibroblasts.Biochem/physiol Actions
AA-CW236 is a cell-permeable chloromethyl triazole (CMT) derivative that acts as a non-pseudosubstrate inhibitor against human O(6)-alkylguanine DNA methyltransferase (MGMT) by targeting MGMT active site Cys145 for covalent modification (KI = 24 nM, kinact = 0.03/min), displaying little affinity toward cysteines from other cellular proteins. AA-CW236 pretreatment (1 μM) effectively prevents MGMT from repairing DNA damage, causing significantly more upregulated O6-alkylguanine accumulation than the pseudosubstrate inhibitor Lomeguatrib (1 μM) when co-administered with the DNA-alkylating agent Temozolomide/TMZ (300 μM) in MCF-7 cells. Likewise, AA-CW236 is shown to boost TMZ toxicity in Caco-2 cultures (IC50 = 227 and 673 μM, respectively, with or without 3 μM AA-CW236 co-treatment).AA-CW236 준비 용품 및 원자재
원자재
준비 용품
AA-CW236 공급 업체
글로벌( 6)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
| DC Chemicals | 021-58447131 13564518121 |
sales@dcchemicals.com | China | 9414 | 58 |
| TargetMol Chemicals Inc. | 4008200310 |
marketing@tsbiochem.com | China | 24131 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 |
cindy.huang@synzest.com | China | 12007 | 58 |