eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem 속성
밀도
1.474±0.06 g/cm3(Predicted)
산도 계수 (pKa)
10.70±0.70(Predicted)
안전
eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem C화학적 특성, 용도, 생산
일반 설명
A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 μM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 ~3 μM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. The solid form of this compound (Cat. No. 324895) is also available.
Biochem/physiol Actions
Cell permeable: yes
eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem 준비 용품 및 원자재
원자재
준비 용품
eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem 공급 업체
