SOPHORIDINE
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SOPHORIDINE 속성
- 녹는점
- 109-110 °C
- 끓는 점
- 396.7±31.0 °C(Predicted)
- 밀도
- 1.16±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- Soluble in ethanol, methanol and water
- 물리적 상태
- powder to crystal
- 산도 계수 (pKa)
- 9.47±0.20(Predicted)
- 색상
- 흰색에서 밝은 노란색
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
안전지침서 | 24/25 | ||
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HS 번호 | 29399990 |
SOPHORIDINE C화학적 특성, 용도, 생산
개요
Sophoridine is a quinolizidine alkaloid isolated from traditional Chinese herbs, which exists in the stems and leafs of Leguminous plant Sophora alopecuroides L., Euchresta japonica Benth., and the roots of Sophora alopecuroides Ait. Sophoridine-induced synchronous oscillations in the hippocampus could elicit the generation and development of seizure. Accumulating evidence demonstrates remarkable pharmacological effects of Sophoridine, including anti-inflammatory, anti-virus and anti-cancer effects.정의
Sophoridine is a quinolizidine alkaloid isolated from leafs of Leguminous plant Sophora alopecuroides.L. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor drug candidate for pancreatic cancer with well-tolerated toxicity.일반 설명
Sophoridine, a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity with 1 as the lead. The structure-activity relationship indicated that introduction of an aliphatic acyl on the nitrogen atom might significantly enhance the anticancer activity. Among the compounds, 6b bearing bromoacetyl side-chain afforded a potential effect against four human tumor cell lines (liver, colon, breast, and lung). The mechanism of action of 6b is to inhibit the activity of DNA topoisomerase I, followed by the S-phase arrest and then cause apoptotic cell death, similar to that of its parent 1.생물학적 활성
Sophoridine is promising to be a novel, potent and selective antitumor drug candidate for pancreatic cancer. It was shown that sophoridine is able to suppress hepatocellular carcinoma in vitro and vivo. Sophoridine dose- and time-dependently blocks the RANKL-induced osteoclasts formation and the activation of ERK and c-Fos as well as the induction and nucleus translocation of NFATc1.Mechanism of action
Sophoridine is an active quinolizidine alkaloid isolated from leaves of Leguminous plant Sophora alopecuroides. L. Accumulating evidence demonstrated that Sophoridine displays remarkable pharmacological effects in inflammatory diseases , infectious diseases and cancers . In particular, Sophoridine and its derivatives have drawn more and more attention owing to their potent anti-tumor effects in different tumor cell lines and animal models. The underlying anti-tumor mechanisms of Sophoridine including increase of intracellular ROS levels, activation of the phosphorylation of ERK and JNK, induction of S phase arrest in pancreatic cancer cells; inhibition of growth and invasion in human colorectal cancer cells via directly binding to MAPKAPK2 and inactivates its phosphorylation; inhibition of ubiquitin-proteasome pathway in human glioma cells.SOPHORIDINE 준비 용품 및 원자재
원자재
준비 용품
SOPHORIDINE 공급 업체
글로벌( 187)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shaanxi Haibo Biotechnology Co., Ltd | +86-02963020060 +86-18629295024 |
hibo06@xaltbio.com | China | 1000 | 58 |
Shanghai Affida new material science and technology center | +undefined15081010295 |
2691956269@qq.com | China | 349 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9354 | 55 |
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3424 | 58 |
Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 |
sales@dolonchem.com | CHINA | 2972 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 3000 | 58 |
Shanghai Standard Technology Co., Ltd. | 18502101150 |
ft-sales@nature-standard.com | CHINA | 1923 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 |
sales@chemnorm.com | CHINA | 2935 | 58 |
SOPHORIDINE 관련 검색:
매트린 1-(3-아미노프로필)-2-피페콜린 3-(디부틸아미노)프로필아민
Sophoridine
Atropine
Sophocarpine
13,14-Didehydromatridin-15-one
phellodendrine
CHELIDONINE
Lycorine hydrochloride
Sophoricoside
1-Acetylpiperidin-4-amine
1-(PIPERIDIN-3-YLMETHYL)PIPERIDINE
1-ACETYL-3-METHYLPIPERIDINE
SOPHORIDINE
N,N-DIMETHYL-3-PIPERIDINEMETHANAMINE
1-Acetyl-4-(methylamino)piperidine
3-(2-ethylpiperidin-1-yl)propan-1-amine