VX-745
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VX-745 속성
- 녹는점
- 261-264 °C
- 끓는 점
- 578.9±60.0 °C(Predicted)
- 밀도
- 1.55±0.1 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- ≥21.8 mg/mL in DMSO; insoluble in H2O; ≥2.1 mg/mL in EtOH with gentle warming and ultrasonic
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- -0.97±0.40(Predicted)
- 색상
- 흰색에서 베이지색
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| HS 번호 | 2933599590 |
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| 그림문자(GHS): |
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| 신호 어: | Warning | ||||||||||||||||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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VX-745 C화학적 특성, 용도, 생산
개요
VX-745 is an inhibitor of p38α MAPK (IC50 = 9 nM). It is selective for p38α over p38β MAPK (Ki = 220 nM) as well as ERK, JNK, and a panel of 50 kinases when used at a concentration of 2 μM. VX-745 inhibits LPS-induced production of IL-1β and TNF-α in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 45 and 51 nM, respectively). It reduces disease severity in a type II collagen-induced mouse model of arthritis when administered at a dose of 10 mg/kg.화학적 성질
Pale Yellow Solid용도
VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome.정의
ChEBI: A member of the class of pyrimidopyridazines that is 6H-pyrimido[1,6-b]pyridazin-6-one substituted at positions 2 and 5 by (2,4-difluorophenyl)sulfanyl and 2,6-dichlorophenyl groups respectivelyVX-745 준비 용품 및 원자재
원자재
준비 용품
VX-745 공급 업체
글로벌( 142)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5909 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
| Xi'an Yutbon Pharmaceutical Technology Co., Ltd | 029-81140587 +8618717328141 |
sales@yutbon.com | China | 437 | 58 |
| Unipharm pharmaceutical industry Co., Ltd | 536-8266195 +8613953676784 |
lee@unipharm-sd.com | China | 1206 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | CHINA | 52867 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
VX-745 관련 검색:
술파디아진 디페닐디클로로실란 디클로로메틸페닐실란 디클로로아이소시안산 나트륨 트리페닐포스핀 염화 티오닐 3,7-디클로로-8-퀴놀린카복실산
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VX 702
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