폴리믹신 B 황산염

폴리믹신 B 황산염
폴리믹신 B 황산염 구조식 이미지
카스 번호:
1405-20-5
한글명:
폴리믹신 B 황산염
동의어(한글):
폴리믹신B황산염;폴리믹신B황산염(POLYMYXINBSULFATE)
상품명:
Polymyxin B sulfate
동의어(영문):
POLYMYXIN B;POLYMYXIN B SULPHATE;POLYMIXIN B SULFATE;AEROSPORIN;POLYMIXIN B SULPHATE;polymyxin B sulfate usp;Polymyxin B sulfate for microbiological assay;N-[3-AMino-1-[[1-[[3-aMino-1-[[6,9,18-tris(2-aMinoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-Methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbaMoyl]propyl]carbaMoyl]-2-hydroxy-propyl]carbaMoyl]pro;Poly-RX;APPLISORB
CBNumber:
CB8666707
분자식:
C56H100N16O17S
포뮬러 무게:
1301.56
MOL 파일:
1405-20-5.mol
MSDS 파일:
SDS

폴리믹신 B 황산염 속성

녹는점
217-220°C (dec.)
저장 조건
2-8°C
용해도
H2O: 50 mg/mL
물리적 상태
가루
산도 계수 (pKa)
pKa 8.9 (Uncertain)
색상
무색 또는 약간 노란색
수소이온지수(pH)
pH (10g/L, 25℃) : 4.5~7.0
optical activity
[α]/D 20/D (Rotation: -2.3 +/- 0.2 degrees)
수용성
50mg/ml/n에서 물에 용해됨
Merck
14,7573
안정성
흡습성
InChIKey
HFMDLUQUEXNBOP-UHFFFAOYSA-N
LogP
-6.361 (est)
CAS 데이터베이스
1405-20-5(CAS DataBase Reference)
EPA
Polymixin B sulfate (1405-20-5)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 22
안전지침서 22-24/25
유엔번호(UN No.) 3249
WGK 독일 3
RTECS 번호 TR1150000
F 고인화성물질 3-8-10
HS 번호 2941 90 00
위험 등급 6.1(b)
포장분류 III
독성 dog,LDLo,intracrebral,320ug/kg (0.32mg/kg),BEHAVIORAL: COMA,British Journal of Pharmacology and Chemotherapy. Vol. 23, Pg. 552, 1964.
기존화학 물질 KE-05-1072
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P312 삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
3 0

폴리믹신 B 황산염 C화학적 특성, 용도, 생산

개요

The polymyxins are cationic peptides originally isolated from B. polymyxa. They bind and kill Gram-negative bacteria. The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B (sulfate) is a mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 and B2 being the two major components. Polymyxin B (sulfate) has rapid in vitro bactericidal activity against major multidrug-resistant Gram-negative bacteria, such as P. aeruginosa, A. baumannii, and K. pneumoniae.

화학적 성질

White Solid

용도

Polymyxin B sulfate is used as topical antibiotic agent, often used in combination with neomycin; products include ointments, creams, eye, and ear drops.

Indications

Polymyxin B is one of a group of cyclic polypeptides elaborated by Bacillus polymyxa. The drug is a surface-active agent. It is thought to alter the lipoprotein membrane of bacteria so that it no longer functions as an effective barrier, thereby allowing the cell contents to escape. Polymyxin B is effective against Pseudomonas, E. coli, and other gram-negative bacteria except the Proteus and Serratia species. It has little effect on gram-positive organisms.

일반 설명

Polymyxin (Aerosporin) was discovered in 1947 almost simultaneouslyin three separate laboratories in the UnitedStates and Great Britain. As often happens whensimilar discoveries are made in widely separated laboratories,differences in nomenclature, referring to both theantibiotic-producing organism and the antibiotic itself, appearedin references to the polymyxins. Because the organismsfirst designated as Bacillus polymyxa and B.aerosporus Greer were found to be identical species, thename B. polymyxa is used to refer to all of the strains thatproduce the closely related polypeptides called polymyxins.Other organisms (e.g., see “Colistin” later) also producepolymyxins. Identified so far are polymyxins A, B1,B2, C, D1, D2, M, colistin A (polymyxin E1), colistin B(polymyxin E2), circulins A and B, and polypeptin. Theknown structures of this group and their properties havebeen reviewed by Vogler and Studer. Of these,polymyxin B as the sulfate usually is used in medicine because,when used systemically, it causes less kidney damagethan the others. Polymyxin B sulfate is a nearly odorless, white to buff powder. It is freely soluble in water and slightly soluble in alcohol.

Clinical Use

Polymyxin B is produced by fermentation of Bacillus polymyxa. It is separated from a mixture of related cyclic peptides and is primarily active against Gram-negative microorganisms. It apparently binds to phosphate groups in bacterial cytoplasmic membranes and disrupts their integrity. It is used IM or IV as a sulfate salt to treat serious urinary tract infections, meningitis, and septicemia, primarily caused by Pseudomonas aeruginosa, but some other Gram-negative bacteria also will respond. Irrigation of the urinary bladder with solutions of polymyxin B sulfate is employed as well by some to reduce the incidence of infections subsequent to installation of indwelling catheters. Additionally, it is used ophthalmically to treat infections by P. aeruginosa. When given parenterally, the drug is neuro- and nephrotoxic and, therefore, is employed only after other drugs have failed.

폴리믹신 B 황산염 준비 용품 및 원자재

원자재

준비 용품


폴리믹신 B 황산염 공급 업체

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