트리틸클로라이드
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트리틸클로라이드 속성
- 녹는점
- 109-112 °C(lit.)
- 끓는 점
- 230-235 °C20 mm Hg(lit.)
- 밀도
- 1.1088 (rough estimate)
- 굴절률
- 1.6281 (estimate)
- 인화점
- 230-235°C/20mm
- 저장 조건
- Store below +30°C.
- 용해도
- 클로로포름: 0.1 g/mL, 투명
- 물리적 상태
- 분말 또는 결정
- 색상
- 흰색에서 회백색 또는 연한 노란색-베이지색
- 수용성
- 물에 불용성. 클로로포름, 헥산, 벤젠, 에테르, 아세톤 및 테트라히드로푸란에 용해됩니다.
- 감도
- Lachrymatory
- BRN
- 397363
- CAS 데이터베이스
- 76-83-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | C,N | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 34-50/53-14-36/37 | ||
| 안전지침서 | 26-36/37/39-45-61-27 | ||
| 유엔번호(UN No.) | UN 3261 8/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | PA6450000 | ||
| F 고인화성물질 | 10-19-21 | ||
| 위험 참고 사항 | Irritant | ||
| TSCA | Yes | ||
| 위험 등급 | 8 | ||
| 포장분류 | III | ||
| HS 번호 | 29036990 | ||
| 유해 물질 데이터 | 76-83-5(Hazardous Substances Data) | ||
| 독성 | LD50 orally in Rabbit: > 5000 mg/kg | ||
| 기존화학 물질 | KE-05735 |
트리틸클로라이드 C화학적 특성, 용도, 생산
물성
물에 용해하지 않고 벤젠, 이류화탄소, 석유에테르 등에 쉽게 용해하며 알콜, 에테르에 미용한다. 물을 흡수한 다음 트리페닐메탄올로 변한다. 융점은 110-112℃, 비등점은 230-235℃(20 mmHg)이다.용도
본제품은 의약화공 영역에서 상용하는 기본유기원료 중 하나이다.보관
용기를 밀폐한 다음 건조하고 통풍이 잘되는 곳에 보관화학적 성질
Triphenylmethyl chloride or trityl chloride (TrCl) is a white to yellow solid. Insoluble in water, easily soluble in benzene, carbon disulfide, petroleum ether, slightly soluble in alcohol and ether, and becomes trityl alcohol after absorbing water. It is an alkyl halide, sometimes used to introduce the trityl protecting group.용도
Trityl Chloride is an alkyl halide commonly used in organic synthesis to introduce the trityl protecting group. Trityl Chloride is used in the preparation of S-trityl-L-cysteine (STLC), a tight-bindin g inhibitor of Eg5 that prevents mitotic progression.주요 응용
Triphenylmethyl Chloride acts as a protecting reagent for amines, alcohols, and thiols. It can be used as a catalyst:Efficient method of tritylation of sensitive compounds and their subsequent detritylation.
In Ritter type synthesis of 1-amidoalkyl-2-naphtols through a one-pot three-component reaction of naphthol, aryl aldehydes and acetonitrile.
In the synthesis of 1,2,4,5-tetrasubstituted imidazoles via a one-pot multi-component reaction of benzil with aldehydes, primary amines, and ammonium acetate.
In the preparation of amido alkyl phenols via one-pot, multi-component reaction of phenols, aromatic aldehydes, and amides under solvent-free conditions.
In one-pot, multi-component synthesis of substituted piperidines using aromatic aldehydes, amines, and β-ketoesters.
Purification Methods
Crystallise trityl chloride from iso-octane. Also crystallise it from 5 parts of pet ether (b 90-100o) and 1 part of acetyl chloride using 1.8g of solvent per g of chloride. Dry it in a desiccator over soda lime and paraffin wax. [Bachman Org Synth Coll Vol III 841 1955, Thomas & Rochow J Am Chem Soc 79 1843 1957, Moisel et al. J Am Chem Soc 108 4706 1986, Beilstein 5 H 750, 5 I 346, 5 II 615, 5 III 2315, 5 IV 2497.] It is moisture sensitive and LACHRYMATORY,트리틸클로라이드 준비 용품 및 원자재
원자재
준비 용품
1-Trityl-1H-imidazole-4-carboxylic acid
N-Boc-S-Trityl-L-cysteine
1H-Imidazole-4-carbaldehyde
2-(AMINOMETHYL)CYCLOPROPANECARBOXYLIC ACID
트리페닐메탄티올
1-Tritylimidazole-4-carboxaldehyde
Acetic acid, [(triphenylmethyl)thio]-
(Z)-2-(2-Aminothiazole-4-yl-)-2-trityloxyimino acetic acid
4-(tritylthio)benzoic acid
트리틸클로라이드 공급 업체
글로벌( 801)공급 업체
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| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
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| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
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| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |