(±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff.
화학적 성질
White Solid
용도
Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix.
s assay and did not induce micronuclei in human lymphocytes.
위험도
Moderately toxic by ingestion. Low toxicity by skin contact.
부작용
May cause localized irritation of the skin with symptoms including redness, rashes and itching.
