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미리스틱 알코올 (N-테트라데칸올)

미리스틱 알코올 (N-테트라데칸올)
미리스틱 알코올 (N-테트라데칸올) 구조식 이미지
카스 번호:
112-72-1
한글명:
미리스틱 알코올 (N-테트라데칸올)
동의어(한글):
미리스틱알코올(N-테트라데칸올);미리스틱알코올;미리스틸알코올;미리스틱알코올(N-테트라데칸올)
상품명:
1-Tetradecanol
동의어(영문):
Epal 14;alfol14;lanettek;loxanolv;myristic;myristyl;Alfol 14;Loxanol V;Lorol C14;dytolr-52
CBNumber:
CB8689436
분자식:
C14H30O
포뮬러 무게:
214.39
MOL 파일:
112-72-1.mol

미리스틱 알코올 (N-테트라데칸올) 속성

녹는점
35-39 °C(lit.)
끓는 점
289 °C(lit.)
밀도
0.823 g/mL at 25 °C(lit.)
증기 밀도
7.4 (vs air)
증기압
<1 hPa (20 °C)
굴절률
1.4454
인화점
>230 °F
저장 조건
−20°C
용해도
water: soluble0.00013g/L at 23°C
물리적 상태
Low Melting Solid, Crystalline Powder, Crystals, Flakes, Pellets and/or Chunks
Specific Gravity
0.823
색상
White
수용성
insoluble
Merck
14,6335
BRN
1742652
CAS 데이터베이스
112-72-1(CAS DataBase Reference)
NIST
1-Tetradecanol(112-72-1)
EPA
1-Tetradecanol(112-72-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 38-36
안전지침서 24/25-26
유엔번호(UN No.) UN 3077 9 / PGIII
WGK 독일 -
RTECS 번호 XB8655000
F 고인화성물질 9
자연 발화 온도 489 °F
TSCA Yes
HS 번호 2905 19 00
위험 등급 9
포장분류 III
유해 물질 데이터 112-72-1(Hazardous Substances Data)
독성 LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 2000 mg/kg
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H410 장기적 영향에 의해 수생생물에 매우 유독함 수생 환경유해성 물질 - 만성 구분 1 경고 P273, P391, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P273 환경으로 배출하지 마시오.
P321 (…) 처치를 하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P332+P313 피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P337+P313 눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

미리스틱 알코올 (N-테트라데칸올) C화학적 특성, 용도, 생산

용도

화장품의피부연화제,계면활성제.

화학적 성질

white low melting solid or flakes

화학적 성질

Myristyl alcohol occurs as a white crystalline solid with a waxy odor. Also reported as opaque leaflets or crystals from ethanol.

용도

myristyl alcohol is an emollient often used in hand creams, cold creams, and lotions to give them a smooth, velvety feel. Sources indicate it as being mildly comedogenic and potentially irritating.

용도

As emollient for cold creams, etc., also for making the sulfated alcohol whose sodium salt is applicable as a "wetter" in textiles.

정의

ChEBI: A long-chain fatty alcohol that is tetradecane in which one of the terminal methyl hydrogens is replaced by a hydroxy group

생산 방법

Myristyl alcohol is found in spermaceti wax and sperm oil, and may be synthesized by sodium reduction of fatty acid esters or the reduction of fatty acids by lithium aluminum hydride. It can also be formed from acetaldehyde and dimethylamine.

일반 설명

Colorless thick liquid (heated) with a faint alcohol odor. Solidifies and floats on water.

공기와 물의 반응

Insoluble in water.

반응 프로필

1-Tetradecanol is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

건강위험

Low toxicity. Overexposure causes some central nervous system depression. Prolonged skin contact causes skin irritation.

Pharmaceutical Applications

Myristyl alcohol is used in oral, parenteral, and topical pharmaceutical formulations. It has been evaluated as a penetration enhancer in melatonin transdermal patches in rats.
Myristyl alcohol has also been tested as a bilayer stabilizer in niosome formulations containing ketorolac tromethamine,and zidovudine.Niosomes containing myristyl alcohol showed a considerably slower release rate of ketorolac tromethamine than those containing cholesterol.This was also observed with the zidovudine formulation.

Safety

Myristyl alcohol is used in oral parenteral, and topical pharmaceutical formulations. The pure form of myristyl alcohol is mildly toxic by ingestion and may be carcinogenic; experimental tumorigenic data are available.It is also a human skin irritant. In animal studies of the skin permeation enhancement effect of saturated fatty alcohols, myristyl alcohol exhibited a lower effect when compared with decanol, undecanol, or lauryl alcohol but caused greater skin irritation.A study investigating contact sensitization to myristyl alcohol revealed that patch testing of myristyl alcohol 10% petrolatum should not be carried out owing to observed irritant effects; thus the use of a lower concentration of myristyl alcohol for such tests (5% petrolatum) was recommended.Myristyl alcohol has been associated with some reports of contact allergy.(8,9)A moderate-to-severe erythema and moderate edema are seen when 75 mg is applied to human skin intermittently in three doses over 72 hours.
LD50(rabbit, skin): 7.1 g/kg
LD50(rat, oral): 33.0 g/kg

저장

The bulk material should be stored in a well-closed container in a cool, dry place.

Purification Methods

Crystallise the alcohol from aqueous EtOH. It has also been purified by zone melting. [Beilstein 1 IV 1864.]

비 호환성

Myristyl alcohol is combustible when exposed to heat or flame. It can react with oxidizing materials. When heated to decomposition, it emits acrid smoke and irritating fumes.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral tablet: sustained-release; and topical formulations: cream, lotion, suspension). Included in nonparenteral (topical cream) formulations licensed in the UK.

미리스틱 알코올 (N-테트라데칸올) 준비 용품 및 원자재

원자재

준비 용품


미리스틱 알코올 (N-테트라데칸올) 공급 업체

글로벌( 203)공급 업체
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Capot Chemical Co.,Ltd.
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+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21726 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30004 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23978 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8922 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
breeduan@crovellbio.com CHINA 2313 58

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