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Bilirubin

Bilirubin 구조식 이미지
카스 번호:
635-65-4
상품명:
Bilirubin
동의어(영문):
Biliyubin;Bilibubin;filirubin;BILIRUBIN;hemetoidin;HEMATOIDIN;1,19-dioxo-;BilirubinGr;Cholerythrin;Bilirubin,99%
CBNumber:
CB8693422
분자식:
C33H36N4O6
포뮬러 무게:
584.66
MOL 파일:
635-65-4.mol

Bilirubin 속성

녹는점
192 °C
끓는 점
641.7°C (rough estimate)
밀도
1.2163 (rough estimate)
굴절률
1.6000 (estimate)
저장 조건
-20°C
용해도
aqueous acid: soluble
물리적 상태
powder
산도 계수 (pKa)
4.62±0.10(Predicted)
색상
orange
수용성
practically insoluble
감도
Light Sensitive
Merck
14,1218
BRN
74376
안정성
Stable. Refrigerate.
EPA
Bilirubin (635-65-4)

안전

위험품 표기 Xn
위험 카페고리 넘버 62-36/37/38-20/21/22
안전지침서 22-24/25-36-26
WGK 독일 2
RTECS 번호 DU3038000
F 고인화성물질 8
TSCA Yes
HS 번호 29339990

Bilirubin C화학적 특성, 용도, 생산

개요

Bilirubin is a yellow breakdown product of heme catabolism, formed when heme is cleaved by heme oxygenase. This reaction produces carbon monoxide and biliverdin, which is rapidly reduced to bilirubin by biliverdin reductase. Bilirubin has key roles as a free radical scavenger with antioxidant and anti-inflammatory actions. Free and albumin-bound bilirubin can also scavenge nitric oxide (NO) and NO-related species. Unconjugated bilirubin is highly water-insoluble and must be conjugated with glucuronides to become water soluble and subsequently excreted by the liver and kidney.

화학적 성질

Light Orange to Deep Redish-Brown Crystalline Solid

용도

Principal pigment of bile and constituent of many biliary calculi

용도

Bilirubin is widely utilized to monitor the liver function and their disease, such as hepatitis or cirrhosis; or the effects of medicines which are damage the liver. It acts as a pigment in certain algae to capture light energy. Its double bonds are isomerizes in the presence of light, which is employed in phototherapy of jaundiced newborns babies. It is used to detect the blocking in bile ducts.

정의

Red coloring matter of bile. Also occurs in blood serum as decomposition product of hemoglobin.

일반 설명

Bilirubin, a heme catabolism end-product is produced by the reduction of its metabolic precursor biliverdin by the action of enzyme biliverdin reductase.

Biochem/physiol Actions

Bilirubin is an active oxidative DNA cleaving agent as well as an effective antioxidant agent, a hydroxyl radical quencher. This bile pigment has both antioxidant and toxic properties. It is a natural inhibitor of vascular smooth muscle cell proliferation (VSMCs). It displays anti-inflammatory and anti-proliferative properties when used as a therapeutic agent in lung/vascular diseases. Serum bilirubin concentration slightly above the normal levels have shown a lesser incidence of heart disease. It is a potential therapeutic agent in heart transplantation and T-cell mediated immune disorders.

Purification Methods

An acyclic tetrapyrrole bile pigment with impurities which can be eliminated by successive Soxhlet extraction with diethyl ether and MeOH. It crystallises from CHCl3 as deep red-brown rhombs, plates or orange-red prisms from chlorobenzene (m 330o dec) and is dried to constant weight at 80o under vacuum. [Gray et al. J Chem Soc 2264, 2276 1961, Beilstein 26 III/IV 3268.]

Bilirubin 준비 용품 및 원자재

원자재

준비 용품


Bilirubin 공급 업체

글로벌( 409)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 886 50
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15418 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086
scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com China 2712 58

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