Domperidone
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Domperidone 속성
- 녹는점
- 240-244°C
- 밀도
- 1.2904 (rough estimate)
- 굴절률
- 1.5400 (estimate)
- 저장 조건
- Store at RT
- 용해도
- DMSO: >10mg/mL
- 산도 계수 (pKa)
- pKa 7.90 (Uncertain)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 하얀색
- 수용성
- 물에 약간 용해됩니다.
- Merck
- 14,3418
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChIKey
- FGXWKSZFVQUSTL-UHFFFAOYSA-N
- CAS 데이터베이스
- 57808-66-9(CAS DataBase Reference)
안전
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 62-63 | ||
안전지침서 | 26-36 | ||
WGK 독일 | 3 | ||
RTECS 번호 | DE2275900 | ||
HS 번호 | 29333990 | ||
기존화학 물질 | KE-05607 |
Domperidone C화학적 특성, 용도, 생산
화학적 성질
White or almost white powder.용도
A novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.정의
ChEBI: 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used s an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet reparations.World Health Organization (WHO)
Domperidone, a peripheral dopaminergic antagonist, was introduced in 1979 for the symptomatic relief of acute nausea and vomiting. The major manufacturer became aware that the injectable formulation was being used in some countries in much higher doses than those recommended to combat nausea and vomiting in cancer patients treated with cytostatic agents. Such use - which was not in conformity with the approved indications - was associated with cardiotoxicity, which in some cases was fatal, and the manufacturer decided to withdraw the injectable dosage form from the market worldwide in January 1985. Suppositories, tablets and a suspension remain available and the manufacturer continues to supply the injection for the treatment of a named patient at the written request of a doctor on the understanding that the appropriate dosage recommendations will be followed.생물학적 활성
Peripheral dopamine D 2 -like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED 50 values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively).Domperidone 준비 용품 및 원자재
원자재
실리카겔
1H-벤즈아미다졸
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester
N,N-다이메틸폼아마이드
요오드화 칼륨
O-클로로니트로벤젠
Hydroxypropyl
클로로포름
4-AMINOCYCLOHEXANECARBOXYLIC ACID
메틸이소부틸케톤
사이안화 칼륨
5-CHLORO-1,3-BENZODIOXOLE
준비 용품
Domperidone 공급 업체
글로벌( 647)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 |
guoyuan@eastchinapharm.com | China | 1615 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
Hebei Lingding Biotechnology Co., Ltd. | +86-18031140164 +86-19933155420 |
erin@hbldbiotech.com | China | 879 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5964 | 58 |
Henan Tengmao Chemical Technology Co. LTD | +8615238638457 |
salesvip2@hntmhg.com | China | 415 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7377 | 58 |
Shaanxi Franta Biotechnology Co., Ltd | +86-13082019107 +86-13082019107 |
admin@flanderff.com | China | 229 | 58 |
Shanghai Affida new material science and technology center | +undefined15081010295 |
2691956269@qq.com | China | 359 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
Domperidone 관련 검색:
1H-벤즈아미다졸 할로페리돌 드로페리돌, 펜타닐 4-(2-케토-1-벤지미다졸린일)피페리딘 N""-[3-(디메틸아미노)프로필]-N,N-디메틸프로판-1,3-디아민 N'-(3-아미노프로필)-N,N-다이메틸-1,3-프로판디아민 3,3'-이미노비스(프로필아민) 클로로디플루오르메탄
Phenformin
DOMPERIDONE MALEATE
DoMperidone EP IMpurity B
DoMperidone-d6
Domperidone Impurity 15
1-(3-chloropropyl)-1,3-dihydro-3-(1-methylvinyl)-2H-benzimidazol-2-one
1-(3-BroMopropyl)-1,3-dihydro-2H-benziMidazol-2-one
1-PIPERIDINECARBOXYLIC ACID, 4-[(4-AMINO-5-CHLOROPHENYL)AMINO], ETHYL ESTER
5-Chloro-1-(4-piperidyl)-2-benzimidazolinone
1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one