1-브로모-3-클로로프로페인

1-브로모-3-클로로프로페인
1-브로모-3-클로로프로페인 구조식 이미지
카스 번호:
109-70-6
한글명:
1-브로모-3-클로로프로페인
동의어(한글):
1-브로모-3-클로로프로판;1-브로모-3-클로로프로페인;1-클로로-3-브로모프로페인;3-브로모-1-클로로프로페인;3-브로모프로필 염화물;3-브로모프로필 클로라이드;3-클로로프로필 브로마이드;3-클로로프로필 브롬화물;w-클로로브로모프로페인;오메가-클로로브로모프로판;오메가-클로로브로모프로페인;트라이메틸렌 클로로브로마이드;트리메틸렌 브롬화물 염화물;트리메틸렌 클로로브롬화물;프로판, 1-브로모-3클로로-;프로페인, 1-브로모-3-클로로-
상품명:
1-Bromo-3-chloropropane
동의어(영문):
BROMOCHLOROPROPANE;3-Chloro-1-bromopropane;I-BCP;1,3-BCP;CHLOROBROMOPROPANE;3-Bromo-1-chloropropane;1-CHLORO-3-BROMOPROPANE;NSC 9183;1,3-Chbp;ω-Chlorobr
CBNumber:
CB8700201
분자식:
C3H6BrCl
포뮬러 무게:
157.44
MOL 파일:
109-70-6.mol
MSDS 파일:
SDS

1-브로모-3-클로로프로페인 속성

녹는점
-59 °C
끓는 점
144-145 °C (lit.)
밀도
1.592 g/mL at 25 °C (lit.)
증기압
7.5 hPa (20 °C)
굴절률
n20/D 1.486(lit.)
인화점
81 °C
저장 조건
room temp
용해도
2.24g/l 불용성
물리적 상태
액체
색상
투명한 액체
폭발한계
3.2-8.6%(V)
수용성
불용성
BRN
605278
안정성
휘발성 물질
CAS 데이터베이스
109-70-6(CAS DataBase Reference)
IARC
2B (Vol. 125)
NIST
Propane, 1-bromo-3-chloro-(109-70-6)
EPA
Propane, 1-bromo-3-chloro- (109-70-6)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 10-22-36/37/38-20/21/22-20/22-68-52/53-37
안전지침서 16-45-36/37/39-26
유엔번호(UN No.) UN 2688 6.1/PG 3
WGK 독일 3
RTECS 번호 TX4113000
TSCA Yes
위험 등급 6.1
포장분류 III
HS 번호 29034980
유해 물질 데이터 109-70-6(Hazardous Substances Data)
독성 LD50 orally in Rabbit: 1100 - 1200 mg/kg LD50 dermal Rat > 2000 mg/kg
기존화학 물질 KE-03643
그림문자(GHS): GHS hazard pictogramsGHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H331 흡입하면 유독함 급성 독성 물질 흡입 구분 3 위험 GHS hazard pictograms P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고 GHS hazard pictograms
H341 유전적인 결함을 일으킬 것으로 의심됨 (노출되어도 생식세포 유전독성을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 생식세포 변이원성 물질 구분 2 경고 P201,P202, P281, P308+P313, P405,P501
H350 암을 일으킬 수 있음 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 1A, 1B 위험 GHS hazard pictograms
H412 장기적 영향에 의해 수생생물에 유해함 수생 환경유해성 물질 - 만성 구분 3 P273, P501
예방조치문구:
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P273 환경으로 배출하지 마시오.
P301+P312 삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
NFPA 704
2
2 0

1-브로모-3-클로로프로페인 MSDS


1-Chloro-3-bromopropane

1-브로모-3-클로로프로페인 C화학적 특성, 용도, 생산

개요

1-Bromo-3-chloropropane is a halogenated alkane compound containing one bromine atom and one chlorine atom in its structure. Due to the high electronegativity of halogens, the molecule of 1-Bromo-3-chloropropane is highly electrophilic and is easily attacked by electrophilic reagents such as nucleophilic reagents, Lewis acid, etc., which undergoes nucleophilic substitution reactions. The compound is relatively stable at room temperature, but is susceptible to elimination reactions at high temperatures or in the presence of strong acids or bases. In addition, prolonged exposure to air should be avoided because 1-Bromo-3-chloropropane molecules contain halogen atoms that are susceptible to reaction by oxygen and moisture in the air to produce products such as alcohols and aldehydes.

화학적 성질

It is a clear and colorless liquid that is soluble in ethanol, ether, and chloroform but insoluble in water.

용도

1-Bromo-3-chloropropane is used in the preparation active pharmaceutical ingredient intermediate such as gemfibrozil and reproterol. It is also involved in the preparation of cardiovascular diseases and analgesic drugs materials. It is utilized as a phase separation reagent for the isolation of ribonucleic acid (RNA) in high quality. It is considered as a replacement of chloroform in nucleic acid separations.

정의

ChEBI: 1-Bromo-3-chloropropane (I-BCP or 109-70-6) is an organochlorine compound that can be used as a safer and equally effective alternative to chloroform. It serves as a phase-separation agent for the one-step method of RNA isolation from biological samples like animal and plant tissue. I-BCP can replace CHCl3 in RNA phase separations.

제조 방법

The most common method for producing 1-Bromo-3-chloropropane is through the free-radical addition of anhydrous hydrogen bromide to allyl chloride. Alternatively, it can be prepared by reacting ethylene with methylene chlorobromide.

일반 설명

1-bromo-3-chloropropane appears as a colorless liquid. Insoluble in water and denser than water. May be toxic by inhalation, ingestion or skin absorption. Used to make pharmaceuticals and other chemicals.

공기와 물의 반응

Insoluble in water.

반응 프로필

Halogenated aliphatic compounds, such as 1-Bromo-3-chloropropane, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

건강위험

Inhalation of vapors or dust is extremely irritating. May cause burning of eyes and flow of tears. May cause coughing, difficult breathing and nausea. Brief exposure effects last only a few minutes. Exposure in an enclosed area may be very harmful. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may cause pollution.

화재위험

Some of these materials may burn, but none ignite readily. Containers may explode when heated.

Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of Cland Br-. See also CHLORINATED HYDROCARBONS, ALIPHATIC; and BROMIDES.

Purification Methods

Wash it with conc H2SO4, water, 10% Na2CO3 solution, water again and then dry with CaCl2 and fractionally distil it just before use [Akagi et al. J Am Chem Soc 78 4034 1956]. [Beilstein 1 H 109, 1 IV 212.]

1-브로모-3-클로로프로페인 준비 용품 및 원자재

원자재

준비 용품


1-브로모-3-클로로프로페인 공급 업체

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